Open Access
Table 5
Sensitivity, specificity, PPV, NPV of each reagent (former and new thresholds), 31.3% prevalence.
Assay/system | Sensitivity (%) [95% CI] | Specificity (%) [95% CI] | PPV (%) | NPV (%) |
---|---|---|---|---|
Elecsys/Cobas 8000 | ||||
Positive ≥ 1.00 | 100 [100–100] | 85.7 [82.0–89.3] | 76.1 | 100 |
Positive ≥ 6.70 | 100 [100–100] | 93.4 [90.8–96.0] | 87.3 | 100 |
Architect/i2000 | ||||
Positive ≥ 1.60 | 43.9 [38.7–49.1] | 100 [100–100] | 100 | 79.6 |
Positive ≥ 0.30 | 97.6 [95.9–99.2] | 85.3 [81.6–89.0] | 75.1 | 98.7 |
Platelia/Evolis | ||||
Positive ≥ 6.00 | 36.6 [31.6–41.6] | 100 [100–100] | 100 | 77.6 |
Positive ≥ 1.02 | 93.9 [91.4–96.4] | 89.0 [85.7–92.2] | 79.5 | 97.0 |
PPV, positive predictive value; NPV, negative predictive value.
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