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Table 5

Sensitivity, specificity, PPV, NPV of each reagent (former and new thresholds), 31.3% prevalence.

Assay/system Sensitivity (%) [95% CI] Specificity (%) [95% CI] PPV (%) NPV (%)
Elecsys/Cobas 8000
 Positive ≥ 1.00 100 [100–100] 85.7 [82.0–89.3] 76.1 100
 Positive ≥ 6.70 100 [100–100] 93.4 [90.8–96.0] 87.3 100
Architect/i2000
 Positive ≥ 1.60 43.9 [38.7–49.1] 100 [100–100] 100 79.6
 Positive ≥ 0.30 97.6 [95.9–99.2] 85.3 [81.6–89.0] 75.1 98.7
Platelia/Evolis
 Positive ≥ 6.00 36.6 [31.6–41.6] 100 [100–100] 100 77.6
 Positive ≥ 1.02 93.9 [91.4–96.4] 89.0 [85.7–92.2] 79.5 97.0

PPV, positive predictive value; NPV, negative predictive value.

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