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Table 3

Kinetic parameters of the disposition of the deficit in haematocrit from baseline in children with persistent early-appearing anaemia following initiation of treatment.

Parameters Artesunate-amodiaquine Artemether-lumefantrine Dihydroartemisinin-piperaquine ALL p value
(n = 10) (n = 18) (n = 34) (n = 62)
Cmaxdihfb (%)
Mean (95% CI) 6.2 (3.8–8.6) 8.4 (6.8–10.1) 7.5 (6.3–8.7) 7.6 (6.7–8.4) 0.25
Tmaxdihfb (day)
Mean (95% CI) 3.3 (1.5–5.1) 2.7 (1.7–3.8) 3.8 (2.6–5.1) 3.4 (2.6–4.1) 0.46
AUCdihfb (%.day)
Mean (95% CI) 72.6 (34.1–111.1) 104.3 (68.8–139.9) 82 (59.6–105.9) 87.4 (70.6–104.1) 0.4
t 1/2dihfb (day)
Mean (95% CI) 2.2 (1.5–2.9) 5.1 (1.8–8.4) 3.7 (2.1–5.3) 3.9 (2.6–5.1) 0.29
K eldihfb (day−1)
Mean (95% CI) 0.3 (0.3–0.4) 0.3 (0.2–0.3) 0.3 (0.2–0.4) 0.3 (0.3 -0.4) 0.26
CLpdihfb (%/day)
Mean (95% CI) 0.7 (0.2–1.2) 0.4 (0.3–0.4) 0.6 (0.4–0.8) 0.6 (0.5–0.7) 0.13
VddiHbfb (L/Kg)
Median (Range) 0.16 (0.04–0.95) 0.17 (0.06–0.43) 0.19 (0.06–0.62) 0.17 (0.04–0.95) 0.8

Cmaxdihfb, maximum deficit in haematocrit from baseline; Tmaxdihfb, time to reach maximum deficit in haematocrit from baseline; AUCdihfb, area under the curve of deficit in haematocrit from baseline versus time; t 1/2def, elimination half-time of deficit in haematocrit from baseline; K eldihfb, elimination rate constant of deficit in haematocrit from baseline; CLpdihfb, volume of blood completely cleared of the deficit in haematocrit from baseline; VddiHbfb, volume of distribution of the deficit in haemoglobin from baseline; L, litre; ALL, all children.

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