Table 3
Kinetic parameters of the disposition of the deficit in haematocrit from baseline in children with persistent early-appearing anaemia following initiation of treatment.
| Parameters | Artesunate-amodiaquine | Artemether-lumefantrine | Dihydroartemisinin-piperaquine | ALL | p value |
|---|---|---|---|---|---|
| (n = 10) | (n = 18) | (n = 34) | (n = 62) | ||
| Cmaxdihfb (%) | |||||
| Mean (95% CI) | 6.2 (3.8–8.6) | 8.4 (6.8–10.1) | 7.5 (6.3–8.7) | 7.6 (6.7–8.4) | 0.25 |
| Tmaxdihfb (day) | |||||
| Mean (95% CI) | 3.3 (1.5–5.1) | 2.7 (1.7–3.8) | 3.8 (2.6–5.1) | 3.4 (2.6–4.1) | 0.46 |
| AUCdihfb (%.day) | |||||
| Mean (95% CI) | 72.6 (34.1–111.1) | 104.3 (68.8–139.9) | 82 (59.6–105.9) | 87.4 (70.6–104.1) | 0.4 |
| t 1/2dihfb (day) | |||||
| Mean (95% CI) | 2.2 (1.5–2.9) | 5.1 (1.8–8.4) | 3.7 (2.1–5.3) | 3.9 (2.6–5.1) | 0.29 |
| K eldihfb (day−1) | |||||
| Mean (95% CI) | 0.3 (0.3–0.4) | 0.3 (0.2–0.3) | 0.3 (0.2–0.4) | 0.3 (0.3 -0.4) | 0.26 |
| CLpdihfb (%/day) | |||||
| Mean (95% CI) | 0.7 (0.2–1.2) | 0.4 (0.3–0.4) | 0.6 (0.4–0.8) | 0.6 (0.5–0.7) | 0.13 |
| VddiHbfb (L/Kg) | |||||
| Median (Range) | 0.16 (0.04–0.95) | 0.17 (0.06–0.43) | 0.19 (0.06–0.62) | 0.17 (0.04–0.95) | 0.8 |
Cmaxdihfb, maximum deficit in haematocrit from baseline; Tmaxdihfb, time to reach maximum deficit in haematocrit from baseline; AUCdihfb, area under the curve of deficit in haematocrit from baseline versus time; t 1/2def, elimination half-time of deficit in haematocrit from baseline; K eldihfb, elimination rate constant of deficit in haematocrit from baseline; CLpdihfb, volume of blood completely cleared of the deficit in haematocrit from baseline; VddiHbfb, volume of distribution of the deficit in haemoglobin from baseline; L, litre; ALL, all children.
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