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Table 2

Serologic and clinical findings in infants with congenital toxoplasmosis born to treated and untreated mothers in the United States.

No. of infants aged 0–180 days*
p value (95% CI)
Treated (n = 25) Untreated (n = 164)
Serologic findings IgM(+)/IgM performed (%) 11/25 (44) 142/164 (86.6) <0.001 (0.04–0.3)
IgA(+)/IgA performed (%) 15/25 (60) 127/164 (77.4) 0.06 (0.18–1.05)
IgE(+)/IgE performed (%) 3/16 (18.7) 41/102 (40.2) 0.1 (0.09–1.28)
Eye disease/n (%) 10/16 (62.5) 119/129 (92.2) 0.003 (0.04–0.46)
Clinical findings Cerebral calcifications/n (%) 13/17 (76.5) 94/118 (79.7) 0.75 (0.24–2.77)
Hydrocephalus/n (%) 5/13 (38.5) 67/99 (67.7) 0.039 (0.09–0.98)
E + C + H/n (%) 3/11 (27.3) 53/86 (61.6) 0.048 (0.05–0.94)
*

Age when first serum was drawn for testing.

E: eye disease, C: calcifications, H: hydrocephalus, n: number of evaluated infants, CI: confidence interval for odds-based parameters.

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