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Review

Table 4

Selected flavonoids and terpenoids (whose presence has been reported in plants of the Asteraceae family) with antiparasitic activity

Flavonoids Organism tested Concentration/dose IC50 References
Four polyoxygenated flavonoids Trypanosoma brucei rhodesiense C1: 16 μM, C2: 18 μM, C3: 21 μM and C4: 11 μM [97]
5,6,7,8,5-Pentamethoxy-3,4-methylenedioxy flavone Trypanosoma brucei rhodesiense; Tb: 6.67 μg/mL [98]
  Trypanosoma cruzi; Tc- > 30 μg/mL  
  Leishmania donovani and Ld: > 30 μg/mL  
  Plasmodium falciparum Pf: 4.57 μg/mL  
5,6,7,5-Tetramethoxy-3,4-methylenedioxyflavone Trypanosoma brucei rhodesiense; Tb: 7.29 μg/mL [98]
  Trypanosoma cruzi; Tc: 19.5 μg/mL  
  Leishmania donovani and Ld: > 30 μg/mL  
  Plasmodium falciparum Pf: 4.26 μg/mL  
5,6,7,8,3,4,5-Hepta-methoxyflavone Trypanosoma brucei rhodesiense; Tb: 4.76 μg/mL [98]
  Trypanosoma cruzi; Tc; 26.4 μg/mL  
  Leishmania donovani and Ld: 5.29 μg/mL  
  Plasmodium falciparum Pf: > 5 μg/mL  
5,6,7,3,4,5-Hexamethoxyflavone Trypanosoma brucei rhodesiense; Tb: 8.58 μg/mL [98]
  Trypanosoma cruzi; Tc: > 30 μg/mL  
  Leishmania donovani and Ld: 8.61 μg/mL  
  Plasmodium falciparum Pf: 2.99 μg/mL  
4-Hydroxy-5,6,7,3,5-pentamethoxyflavone (ageconyflavone C) Trypanosoma brucei rhodesiense; Tb: 3.01 μg/mL [98]
  Trypanosoma cruzi; Tc: > 30 μg/mL  
  Leishmania donovani and Ld: 3.56 μg/mL  
  Plasmodium falciparum Pf: 3.59 μg/mL  
3, 5, 7, 3’-Tetrahydroxy-4’-methoxyflavone Plasmodium falciparum [23]
Bractein Leishmania donovani [54]
Kaempferol Giardia lamblia 26.47 μg/mL [17]
Quercetin Giardia lamblia 8.73 μg/mL [17]
(−)-Epicatechin Giardia lamblia 1.64 μg/mL [17]
(−)-Epigallocatechin Giardia lamblia 8.06 μg/mL [17]
Quercetin Haemonchus contortus 250 μg/mL as highest concentration [57]
Luteolin Haemonchus contortus 250 μg/mL as highest concentration [57]
  Leishmania donovani 0.8 μg/mL [148]
Quercetin Leishmania donovani 1 μg/mL [148]
Fisetin Leishmania donovani 0.6 μg/mL [148]
3-Hydroxyflavone Leishmania donovani 0.7 μg/mL [148]
Luteolin Plasmodium falciparum 3D7 and 7G8 3D7: 11 μg/mL [66]
    7G8: 12 μg/mL  
Terpenoids      
Vernodalin Plasmodium falciparum 4 μg/mL [100]
Vernodalol Plasmodium falciparum 4.2 μg/mL [100]
Vernolide Plasmodium falciparum 8.4 μg/mL [100]
Hydroxyvernolide Plasmodium falciparum 11.4 μg/mL [100]
16,17- Dihydrobrachycalyxolide Plasmodium falciparum (K39, 3D7, V1/S and Dd2) K39: 4.2 μg/mL [101]
    3D7: 13.7 μg/mL  
    V1/S: 3 μg/mL  
    Dd2: 16 μg/mL  
Tagitinin C Plasmodium falciparum 0.75 μg/mL [38]
15-Acetoxy-8 β-[(2-methylbutyryloxy)]-14-oxo-4, 5-cis-acanthospermolide) Plasmodium falciparum 3D7 2.9 μg/mL [34]
9 α-Acetoxy-15-hydroxy- 8 β-(2-methylbutyryloxy)-14-oxo- 4,5-Trans-acanthospermolide Plasmodium falciparum 3D7 2.23 μg/mL [34]
3 β-Hydroxyolean-12-en-28-oic acid (oleanolic acid) Leishmania amazonensis La: > 100 μg/mL [116,162], [161]
  Leishmania braziliensis  
3 β-Hydroxyurs-12-en-28-oic acid (ursolic acid) Leishmania infantum Li: 7.4 μM [89]
  Trypanosoma brucei Tb: 2.2 μM  
  Trypanosoma cruzi Tc: 8.8 μM  
  Plasmodium falciparum Pf: 29.7 μM  
Indicusalactone Plasmodium falciparum 2.8 μg/mL [132]
(−)-Oxyfrullanolide Plasmodium falciparum 3.8 μg/mL [132]
7-Hydroxyfrullanolide, Plasmodium falciparum 2.5 μg/mL [132]
Squalene Plasmodium falciparum 2.3 μg/mL [132]
3,5-Di-O-caffeoylquinic acid methyl ester Plasmodium falciparum 2.4 μg/mL [132]
(3s)-16,17-Didehydrofalcarinol Leishmania mexicana 0.48 μM [76]
Ursolic acid Leishmania amazonensis 6.4 μg/mL [162]
  Leishmania infantum In vivo 1.0 mg/kg body weight (mice) [49]
Urs-12-ene-3 β,16 β-diol Plasmodium falciparum Pf: 9.7 μM [89]
  Leishmania infantum Li: 9.3 μM  
  Trypanosoma cruzi Tc: 9.9 μM  
  Trypanosoma brucei Tb: 2.3 μM  
3 β,11α-Dihydroxyurs-12-ene Plasmodium falciparum Pf: 23.9 μM [89]
  Leishmania infantum Li: 3.2 μM  
  Trypanosoma cruzi Tc: 8.1 μM  
  Trypanosoma brucei Tb: 7.8 μM  
Betulinic acid Caenorhabditis elegans 100 μg/mL [22]
  Plasmodium falciparum W2 2.33 μg/mL [91]
β-Sitosterol Trypanosoma brucei brucei S427 12.5 μg/mL [99]

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