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Figure 2.


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Role of diet AGE in perpetuating oxidant stress and pro inflammatory cytokines production with deleterious effect on immunity. Abbreviation: AGE: Advanced glycation endproducts; Cdc42-Rac: cell division control protein 42 homolog-Rac; ERK1/2: extracellular signal-regulated kinase ½; FOXO: forkhead box protein O subclass; HMGB1: High mobility group box 1; IkB: Inhibitor of Nuclear factor B; IKK: Inhibitor of nuclear factor B kinase; JAK: Janus kinase; JNK: c-jun N-terminal kinase;  MAC-1: macrophage-1 antigen; NADPH: nicotinamide adenine dinucleotide phosphate;  NF kB: Nuclear factor kapa B; P38MAPK: Mitogen associated protein kinase P38; RAGE: receptor for Advanced glycation endproducts; ROS: reactive oxygen species; SAPK: stress-activated protein kinase; STAT: signal transducer and activator of transcription; TLR: Toll-Like Receptor.

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