Table 1.
Cell types, parasite strains and IFN-γ effects on pro-inflammatory protein expressions. Pro-inflammatory proteins were analysed in supernatants of cultivated RH- or PRU-infected cells using Proteome Profiler Array. All spots were quantified as pixel units by GeneTools. Quantification corresponds to the pixel values of uninfected cells (negative control) subtracted from pixel values of infected cells. The effect level was determined using the Scheirer-Ray-Hare test and Steel-Dwass and/or Siegel-Castellan post hoc tests. ↘ expression decrease with p < 0.05; ↘↘ expression decrease with p < 0.001. ↗ expression increase with p < 0.05; ↗↗ expression increase with p < 0.001.
| Cells |
CMH5 |
Hbmec |
SH SY5Y |
||||
|---|---|---|---|---|---|---|---|
| Strains proteins | RH | PRU | RH | PRU | RH | PRU | |
| Interleukins | IL-6 | – | – | ↘ | ↘ | – | – |
| IL-8 | – | – | – | – | – | – | |
| Chemokines | MIF | – | – | – | ↘ | – | – |
| MCP-1 | – | ↘↘ | – | ↘↘ | ↘ | – | |
| GROα | – | – | – | ↘ | – | – | |
| Growth factors | G-CSF | ↘↘ | ↘↘ | ↘↘ | ↘↘ | ↗ | ↘ |
| GM-CSF | – | ↘↘ | ↘ | – | – | ↘ | |
| Other | SlCAM | – | ↘↘ | – | ↘↘ | ↗↗ | ↗↗ |
| Serpin El | – | ↘↘ | – | ↘↘ | ↗↗ | ↗↗ | |
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