Multilocus microsatellite typing of Leishmania and clinical applications: a review

Open Access

Review

Table 1.

Leishmania Microsatellite markers. Classification has been made according to the number of citations in the literature. The number of alleles is listed under the species and represents the range found in the different studies. Whereas some markers have been used only once, others have been used several times and the number of strains is different from one study to another. These two points can explain the differences in allele numbers between the loci. The number of alleles is thus subject to change with other studies.

	Subgenus Leishmania
Markers	L. (L.) donovani/L. (L.) infantum		References
^† Lm4TA	33–11		[14]
^† LIST7039 t	1–14		[27]
^† Li71-33	1–15		[45]
^† Lm2TG	1–18		[14]
^† Li22-35	1–18		[45]
^† Li45-24	1–13
^† TubCA	1–9
^† Li71-7	2–8
^† Li23-41	1–23
^† Li71-5/2	1–4
^† LIST7031	1–11		[27]
^‡ Li46-67	1–4		[45]
^† Li41-56	2–9		[45]
^‡ CS20	1–12		[36]
^‡LIST7028^mt	2–3		[27]
^†LIST7033^mt	4–6
^‡LIST7027^t	3–4
^‡LIST7029	1–4
ITS1	^*		[21]
^‡LIST7030^mt	1–3		[27]
^†LIST7035^mt	3–4
^†LIST7037^t	4–5
^‡LIST7040^t	1–4
^†LIST7021	3–4
^‡LIST7023	1–3
^‡LIST7024	3–7
^†LIST7025	3–8
^†ISA136	3		[48]
^‡ST436	4		[48]
LIST7010^mt	3		[26]
LIST7011^mt	2–3		[26]
^‡LIST7036^mt	4		[27]
^‡LIST7022	2–3
^†LIST7026	2–6
^†LIST7032	2–3
^‡LIST7034	3–5
^†LIST7038	3
CS19	4–8		[36]
^‡Li71-19	1		[45]
^‡Li72-14	1
^†Li72-20	4
^‡DPB1	3–4		[50]
^‡DPB2	3–6
^‡HG	3–6
^‡Rossi1	2–5
^†Rossi2	5
LIST7001^m	2		[26]
LIST7002^m	1
LIST7003^m	2
LIST7004^m	1
LIST7005^m	2
LIST7006^m	1
LIST7007^m	1
LIST7008^m	2
LIST7009^m	2
LIST7012^m	2
LIST7013^m	2
^†LiBTG	8		[25]
^†LiBTA	7		[25]
^‡Li21-34	Uk		[45]
^‡Li71-42	Uk
^‡Li72-17/2	Uk
Markers	L. (L.) major		References
LIST7028	3		[27]
LIST7033	4
LIST7030	3
LIST7035	4
LIST7036	4		[26]
LIST7010	4		[26]
LIST7011	2–5		[58]
4GTG^t	2–3		[58]
27GTG^t	3		[5]
36GTG	3–4
39GTG	2–5
45GTG	5–7
IGC	2
28AT	5–6
7IAT	3–9
IGACA	1–3
ICA	4–7
LIST7001	4		[26]
LIST7002	5
LIST7003	3
LIST7004	4
LIST7005	4
LIST7006	4
LIST7007	4
LIST7008	2
LIST7009	5
LIST7012	3
LIST7013	3
Markers	L. (L.) tropica		References
LIST7039	5–15		[27]
LIST7028	3
LIST7033	4–5
LIST7027	4–10
LIST7030	3
LIST7035	4
LIST7036	4–7
LIST7037	4
LIST7040	4–7
LIST7010	3–9		[26]
LIST7011	2–8		[26]
GA1	2–3		[58]
GA2	6–8
GA3	3–8
GA6	3
GA9	2–4
GA10	3–5
GA11	4
Mix9	2
GM2	3–4
GTG1	3
GTG3	3–5
GT4	4–6
GACA4	2
GACA1	3
4GTG	3
27GTG	4
Subgenus Viannia
Markers	L. (V.) braziliensis	L. (V.) guyanensis	References
AC01/AC01R	4–16	4–10	[55]
AC16/AC16R	8–14	2–5
AC52	19–22	4–10
ITSbraz	6	2–5	[54]
LRC	12–15	5–8
EMI	12–14	7–9
GO9	7–10	4–5
E11	6–9	3–7
ARP	15–18	7–8
Ibh3	5–9	3–8
CAK	8–13	5–6
LBA	8–14	3–7
CSg46	9–14	4–5	[46]
CSg47	14–29	11
CSg53	3–13	2–4
CSg55	2–13	6–12
CSg59	3–7	3
7GN	10–17	3–5
11H	4–17	6–8
11C	6–17	3–4
6F	8–16	3–8
10F	4–9	2
B6F	12–16	3–4
B3H	10–14	4–5
CSg48	4–19	2–4

The 14 first microsatellite markers (in bold) are the most used in L. (L.) donovani/L. (L.) infantum studies. Markers used for several species are tagged with ^t and/or ^m for L. (L.) tropica and/or L. (L.) major, respectively.

The region ITS1 contains several microsatellites and polymorphisms can only be detected by sequencing.

^†

mean polymorphism obtained within zymodeme MON-1.

^‡

mean polymorphism obtained among zymodemes.

Thirty microsatellite markers have been developed by Kebede et al. [31] for L. (L.) aethiopica. Uk: Unknown.

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