Afoxolaner against fleas: immediate efficacy and resultant mortality after short exposure on dogs

Open Access

Table 2

Observed prophylactic efficacy of afoxolaner and induced mortality of fleas after 6 h of exposure on dogs.

	Observed efficacy on dogs (Live fleas removed from dogs)				Induced mortality (Live fleas counted after 24 h in insectarium)
	Control group (n = 6)	Treated group (n = 10)			Control group (n = 6)	Treated group (n = 10)
Infestation day	Arithmetic mean	Arithmetic mean (Eff%)	Geometric mean¹ (Eff%)	p-value²	Arithmetic mean	Arithmetic mean (Eff%)	Geometric mean¹ (Eff%)	p-value²
Day 2	94.2	4.2 (95.5)	1.7 (98.2)	0.0012^*	93.7	0.6 (99.4)	0.3 (99.7)	0.0006^*
Day 7	74.7	2.5 (96.7)	1.8 (97.5)	0.0013^*	64.0	0.0 (100.0)	0.0 (100.0)	0.0008^*
Day 14	80.2	8.1 (89.9)	7.1 (90.9)	0.0014^*	50.7	0.0 (100.0)	0.0 (100.0)	0.0012^*
Day 21	71.8	27.4 (61.9)	22.4 (68.3)	0.0056^*	59.3	2.2 (96.3)	1.8 (96.7)	0.0012^*
Day 28	89.7	63.7 (29.0)	63.2 (29.2)	0.0014^*	72.8	25.8 (64.6)	18.5 (73.3)	0.0048^*

Computed as the anti-logarithm of the arithmetic mean of the log-counts and then subtracting 1.

(Two-sided) Probability value associated with the comparison of the population means of the two treatment groups.

Significant difference.

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