Selection methods for resistance to and tolerance of helminths in livestock

Novel Approaches to the Control of Parasites in Goats and Sheep. Invited editors: Hervé Hoste, Smaragda Sotiraki and Michel Alvinerie

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Table 1.

Summary of quantitative trait loci for gastrointestinal nematode resistance in sheep.

Reference	QTL found or nearest marker	Chromosome number	Loci studied	Trait used
[12]	OARJMP29, McM130, McM357, TGLA67, OarVH130, McMA22, McM214,	1, 3, 6, 11, 12, 20	Genome-wide	FEC
[15]	BMS360, CSSM3, BM6465, CSAP39E, MCM158, RM96, CSSM37, MCM140, CMCA52, CSAP36E, CSSME76, MAF45, BM2818, FCB128	X, 1, 6, 12	251 markers – genome-wide	strongyle faecal egg count (FEC), the coccidia faecal oocyst count (FOC) and a count of keds (Melophagus ovinus)
[23]	None	20	MHC	FEC
[25]	None	20	MHC	faecal scouring
[33]	OMHC1, OLADRB1, OLADRB2	20	OMHC1, OLADRB1, OLADRB2	faecal egg count (FEC), blood packed cell volume (PCV), antibody (AB) levels, serum proteins (SP) and blood eosinophil count (EOS)
[37]	o(IFN)-γ	3	o(IFN)-γ	FEC, IgA
[38]	BM81124, BM3215, BM3215, BM9202, ILSTS65, ILSTS42	8, 11, 23	Genome-wide	FEC, total serum IgE, serum IgGspecific for the T. colubriformis L3 larvae
[40]	IFNG, MHC	2, 3, 14, 20	139 Microsatellite markers on Chr 1, 2, 3, 5, 14, 18, 20, 21	IgA, FEC
[43]	EPCDV010, ILSTS044	1	18 microsatellite markers	FEC, Nr adult larvae
[57]	OMCH1	20	MHC Class I	-
[58]	OLADRB1	20	MHC Class II	-
[62]	None	20	MHC Class II	FEC
[63]	OarCP73, DYMS1, BM1815	20	MHC	haemotocrit level, FEC, igL
[65]	Ovar-DQA1	20	MHC Class II	Transcription profiles
[77]	Between AC113228 & ILSTS62 and CP26 & BMS648; between markers URB060 & MCMA13; between markers ILSTS28 & ILSTS45; between markers DU363924 & BMS2572 and MCM37 & MCM137	1, 3, 4	223 markers in Genome scan	FEC
[85]	16 genomic regions including CD53, CHI3L2, CHIA, DENND2D, RELN, NSUN2, HRH1	1, 4, 16, 19	Genome-wide	Selection signatures
[88]	Not specified	5, 12, 13, 21	50 K SNP chip	FEC
[94]	OLADRB	3	MHC	FEC
[95]	IFNG region BL4; BMS1617	3	fine mapping	FEC
[97]	INRA132 CP101	20	BM1818, OarCP73, OarHH56, DYA, OLADRB, CP101, OMHC1, DQA2, DQA1, TFAP2A, DQBA27, Bf94_1, and INRA132	FEC
[102]	IRF3, TGF-B1 among others	4, 12, 14, 19, 20, as well as OAR1, 3, 4, 5, 7, 12, 19, 20 and 24 at suggestive level	Meta-analysis – Illumina OvineSNP50 BeadChip	FEC
[107]	s39968, OAR12_62301297, OAR12_62347621, OAR12_62371899	7, 9, 14, 15, 21, 4, 5, 6, 8, 12, 17, 18, 19, 23, 21, 13	160 microsatellite markers were used as well as the Illumina OvineSNP50 BeadChip	FEC, PCV, worm burden, length of females, IgG, and pepsinogen concentration
[111]	MHC-DRB1	20	MHC-DRB1	FEC
[119]	MHC-DRB1	20	MHC-DRB1	FEC, lymphocyte antigen

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