Preventive efficacy of Frontline® Combo and Certifect® against Dipylidium caninum infestation of cats and dogs using a natural flea (Ctenocephalides felis) infestation model

Open Access

Table 2.

Summary of the schedule of operations.

Operation	Cats	Dogs
Acclimatisation	Days −14 to −1	Days −7 to −1
Flea infestation with 100 non infected fleas for randomisation purposes	Day −11	Day −7
Ranking and allocations to groups	Days −3 or −2	Days −3 or −2
Flea infestations with 100 (cats) or 250 (dogs) fleas from a population of D. caninum infected fleas	Days 0, +7, +14, +21 and +28	Days 0, +7, +14, +21,+28, +35, +42, +49, +56
Administration of treatment	Day 0	Day 0
Flea counts¹	Days −9, +2, +9, +16, +23 and +30	Days −6, +2, +9, +16, +23, +30, +37, +44, +51, +58
Monitoring for expelled D. caninum proglottids	Days −14; −1; and daily from Day +21 to Day +60	Days −1, and then Daily from Day +21 to Day +86

Fleas (except on Days −5 and −10) were counted and placed back on the cats and dogs 48 ± 2 h post-infestation.

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