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Identification of a specific motif in the GDP-MP of L. infantum.
A. Multiple sequence alignment of T. maritima, L. infantum and human GDP-MPs. The specific motif of the L. infantum GDP-MP catalytic pocket is underlined with a full line. Note the presence of the signature motif F(V)EKP (underlined with a dashed line) in these three enzymes.
B. Interactions mediated between GDP-mannose (purple) and the F(V)EKP conserved motif of the L. infantum GDP-MP (green). The amino acids of the conserved motif (yellow) are represented in sitck. The red lines represent H-bonds. The specific motif is colored in white.
C. Interactions mediated between GDP-mannose (purple) and the specific motif of the L. infantum GDP-MP (green). The amino acids of the specific motif (white) are represented in stick. The red lines represent H-bonds. The F(V)EKP conserved motif is colored in yellow.
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