Comparison of human and L. infantum GDP-MP models.

A. Superposition of human and L. infantum GDP-MP 3D models. Ribbon-tubes in green and orange represent the L. infantum and the human GDP-MPs, respectively. The F(V)EKP conserved motif is colored in yellow.

B. Position of the GDP-mannose in both human and L. infantum GDP-MPs. This figure represents the superposition of both human and L. infantum GDP-MPs including the substrate GDP-mannose (purple). The position of the GDP-mannose was determined by docking. Ribbon-tubes in green and orange represent the L. infantum and the human GDP-MPs, respectively. The F(V)EKP conserved motif is colored in yellow.