Table I.
Effect of FQ (SSR97193 – IC50 and 95% confidence intervals) on P. falciparum clinical isolates from different studies.
| Ferroquine |
Chloroquine |
Artesunate |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Country | n | IC50 (nM) (ng/mL) | 95% CI | N | IC50 (nM) (ng/mL) | 95% CI | % resistance | n | IC50 (nM) (ng/mL) | 95% CI | Reference | |
| Gabon | 103 | 10.8 | 8.6-13.5 | 102 | 370 | 319-429 | 95 (a) | 65 | 2.9 | 2.3-3.7 | Biot et al., 1999 | |
| 4.7 | 3 . 8-5.9 | 118.4 | 102-137 | 1.1 | 0.9-1.4 | |||||||
| Senegal | 55 | 7.9 | 6.5-9.7 | 53 | 102 | 74-140 | 55 (a) | 51 | 1.9 | 1.5-2.3 | Biot et al., 2006a | |
| 3.4 | 2.8-4.2 | 32.6 | 23.7-44.8 | 0.7 | 0.6-0.9 | |||||||
| Gabon | 56 | 16 | 14.4-17.8 | 56 | 141 | 70-285 | 52 (a) | nt | nt | nt | Daher, et al., 2006a | |
| 6.9 | 6.3-7.8 | 45.1 | 22.4-91.2 | |||||||||
| Gabon | 60 | 27.9 | 2.3-33.2 | 60 | 398 | 166-956 | 97 (a) | nt | nt | nt | Daher, et al., 2006a | |
| 12.1 | 1.0-14.5 | 127.3 | 53.1-306 | |||||||||
| Thailand | 65 | 9.3 | 8.7-10.0 | 62 | 341 | 304-382 | 100 (a) | 56 | 4.0 | 3.1-6.3 | Daher, et al., 2006b | |
| 4.0 | 3.8-4.4 | 109.1 | 87.2-122 | 1.5 | 1.2-2 .4 | |||||||
| Gabon | 40 | 1.9 | 0.6-6.7 | 43 | 113 | 12.4-332 | 100 (b) | 43 | 1.0 | 0.2-6.0 | Delhaes et al., 2001 | |
| 0.8 | 0.3-3.0 | 36.1 | 4.0-106 | 0.4 | 0.1-2.3 | |||||||
| Cambodia | 155 | 29 | 26.3-31.6 | 155 | 135 | 121-151 | 32 (a) | 150 | 1.1 | 1.0-1.2 | EVT0231 | |
| 12 6 | 11.6-13.8 | 43.1 | 38.7-48.2 | 0.4 | 0.4-0.5 | |||||||
n = number of clinical sites; nt = not tested; CI = confidence interval; IC50 = inhibitory concentration decreasing a response by 50%; (a) = % of resistance using the threshold level of resistance IC50 > 100 nM; (b) = % of resistance using the threshold of IC99 > 30 nM for the HRP2 detection assay. For values in italics, units = ng/mL, calculated for translation to a free-base or free-acid gravimetric concentration.
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