Issue |
Parasite
Volume 20, 2013
|
|
---|---|---|
Article Number | 11 | |
Number of page(s) | 5 | |
DOI | https://doi.org/10.1051/parasite/2013011 | |
Published online | 29 March 2013 |
Research Article
First isolation and genetic characterization of a Toxoplasma gondii strain from a symptomatic human case of congenital toxoplasmosis in Romania
Premier isolement avec caractérisation génétique d’une souche de Toxoplasma gondii en Roumanie, à partir d’un cas humain symptomatique de toxoplasmose congénitale
1
Department of Microbiology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Louis Pasteur street, Cluj-Napoca 400349, Romania
2
Department of Medical Informatics and Biostatistics, “Iuliu Haţieganu” University of Medicine and Pharmacy, 6 Louis Pasteur street, Cluj-Napoca 400349, Romania
3
Department of Neonatology, “Iuliu Haţieganu” University of Medicine and Pharmacy, 57 Bulevardul 21 Decembrie 1989, Cluj-Napoca 400124, Romania
4
Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 3–5 Mănăştur street, Cluj-Napoca 400372, Romania
5
Centre National de Référence (CNR) Toxoplasmose/Toxoplasma Biological Resource Center (BRC), Centre Hospitalier-Universitaire Dupuytren, Limoges 87042, France
6
INSERM UMR 1094, Neuroépidémiologie Tropicale, Laboratoire de Parasitologie-Mycologie, Faculté de Médecine, Université de Limoges, Limoges 87025, France
* Corresponding author: hcolosi@umfcluj.ro
Received:
21
February
2013
Accepted:
19
March
2013
Very limited data exists on the genetic diversity of Toxoplasma gondii from Eastern Europe. We present the first Romanian case of symptomatic congenital toxoplasmosis in which the T. gondii strain was isolated after inoculation in mice of a cerebrospinal fluid sample from a living neonate. The T. gondii strain was genotyped with 15 microsatellite markers distributed on 10 of the 14 chromosomes of T. gondii. The strain had a type II genotype.
Résumé
Il existe très peu de données sur la diversité génétique de Toxoplasma gondii en Europe de l’Est. Nous présentons le premier cas humain de toxoplasmose congénitale en Roumanie dans lequel la souche de T. gondii a été isolée chez la souris après inoculation d’un échantillon de liquide céphalo-rachidien d’un nouveau-né vivant. La souche de T. gondii a été génotypée avec 15 marqueurs microsatellites localisés sur 10 des 14 chromosomes de T. gondii. La souche avait un génotype de type II.
Key words: Congenital toxoplasmosis / Genotyping / Eastern Europe
© C.A. Costache et al., published by EDP Sciences, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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