| Issue |
Parasite
Volume 18, Number 1, February 2011
|
|
|---|---|---|
| Page(s) | 3 - 11 | |
| DOI | https://doi.org/10.1051/parasite/2011181003 | |
| Published online | 15 February 2011 | |
Review
Clinical and translational research in Pneumocystis and Pneumocystis pneumonia*
La recherche clinique sur le Pneumocystis et la Pneumocystose pulmonaire
Division of Pulmonary and Critical Care Medicine and HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, USA
** Correspondence: Laurence Huang, M.D., HIV/AIDS Division, Ward 84, San Francisco General Hospital, 995 Potrero Avenue, San Francisco, CA 94110, USA Tel.: (415) 476-4082, extension 406 – Fax: (415) 476-6953 E-mail: lhuang@php.ucsf.edu
Received:
24
August
2010
Accepted:
11
October
2010
Pneumocystis pneumonia (PcP) remains a significant cause of morbidity and mortality in immunocompromised persons, especially those with human immunodeficiency virus (HIV) infection. Pneumocystis colonization is described increasingly in a wide range of immunocompromised and immunocompetent populations and associations between Pneumocystis colonization and significant pulmonary diseases such as chronic obstructive pulmonary disease (COPD) have emerged. This mini-review summarizes recent advances in our clinical understanding of Pneumocystis and PcP, describes ongoing areas of clinical and translational research, and offers recommendations for future clinical research from researchers participating in the “First centenary of the Pneumocystis discovery”.
Résumé
La pneumocystose pulmonaire (PcP) est responsable d’une importante morbidité et mortalité chez les personnes immunodéprimées, particulièrement celles qui sont porteuses du virus de l’immunodéficience humaine (VIH). L’infection par le Pneumocystis s’observe de plus en plus, tant dans des populations immunodéprimées qu’immunocompétentes, et notamment chez des personnes atteintes de broncho-pneumopathies chroniques obstructives (BPCO). Cette mise au point recense les données récentes qui concernent la clinique de l’infection par le Pneumocystis, notamment la PcP, et les recommandations et les recherches en cours dans le domaine, telles qu’elles ont été présentées lors de la conférence commémorant le premier centenaire de la découverte de Pneumocystis.
Key words: Pneumocystis / colonization / Pneumocystis pneumonia (PcP) / human immunodeficiency virus (HIV) / acquired immune deficiency syndrome (AIDS)
Mots clés : Pneumocystis / infection / pneumocystose pulmonaire (PcP) / virus de l’immunodéficience humaine (VIH) / syndrome de l’immunodéficience acquise (SIDA)
© PRINCEPS Editions, Paris, 2011, transferred to Société Française de Parasitologie
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