Volume 15, Number 3, September 2008Xth European Multicolloquium of Parasitology (EMOP-10, Paris, August 24-28, 2008)
|Page(s)||379 - 383|
|Published online||15 September 2008|
Xth EMOP, August 2008
Protective immunity against malaria liver stage after vaccination with live parasites
Laboratory of Malaria Immunobiology, Singapore Immunolog Network, AFSTAR (Agency for Science, Technology and Research), Immunos, Singapore 138673, Singapore
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Despite nearly 100 years of research and control efforts, malaria remains one of the most important infectious diseases. An efficient vaccine would be a powerful to tool to reduce mortality and morbidity. Experimentally, induction of sterile immunity in humans after vaccination with attenuated sporozoites has been obtained. This observation has spurred the search for subunit vaccines that aim to reproduce this protection. As yet none of the current candidate subunit vaccines achieved complete protection reproducibly. This failure coupled to the recent advent of genetically modified Plasmodium parasites has led to a renewed interest in the use of live parasites for vaccination against malaria pre-erythrocytic stages. In this article, we review and discuss the recent developments in this field.
Key words: malaria / vaccine / live parasite
© PRINCEPS Editions, Paris, 2008, transferred to Société Française de Parasitologie
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