Volume 15, Number 3, September 2008Xth European Multicolloquium of Parasitology (EMOP-10, Paris, August 24-28, 2008)
|Page(s)||237 - 243|
|Published online||15 September 2008|
Xth EMOP, August 2008
Molecular crosstalks in Leishmania-sandfly-host relationships
Department of Parasitology, Faculty of Sciences, Charles University, Vinicna 7, Prague 2, 128 44 Czech Republic
* Correspondence: Petr Volf. Tel.: ++4202 2195 1815 – Fax: ++4202 2491 9704. E-mail: email@example.com
Sandflies (Diptera: Phlebotominae) are vectors of Leishmania parasites, causative agents of important human and animal diseases with diverse manifestations. This review summarizes present knowledge about the vectorial part of Leishmania life cycle and parasite transmission to the vertebrate host. Particularly, it focuses on molecules that determine the establishment of parasite infection in sandfly midgut. It describes the concept of specific versus permissive sandfly vectors, explains the epidemiological consequences of broad susceptibility of permissive sandflies and demonstrates that genetic exchange may positively affect Leishmania fitness in the vector. Last but not least, the review describes recent knowledge about circulating antibodies produced by hosts in response to sandfly bites. Studies on specificity and kinetics of antibody response revealed that anti-saliva IgG could be used as a marker of host exposure to sandflies, i.e. as a useful tool for evaluation of vector control.
Key words: Leishmania / sandfly / host
© PRINCEPS Editions, Paris, 2008, transferred to Société Française de Parasitologie
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.