Volume 15, Number 3, September 2008Xth European Multicolloquium of Parasitology (EMOP-10, Paris, August 24-28, 2008)
|Page(s)||206 - 210|
|Published online||15 September 2008|
Xth EMOP, August 2008
Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure
Laboratoire Adaptation et Pathogénie des Micro-organismes, Université Joseph Fourier Grenoble 1, BP 170, F-38042 Grenoble cedex 9, France
2 CNRS UMR 5163 – ATIP+ group
* Correspondence: Mohamed-Ali Hakimi. Tel.: 33 (0)4 76 63 74 69 – Fax: 33 (0)4 76 63 74 97. E-mail: Mohamed-Ali.Hakimi@ujf-grenoble.fr
The activity state of a gene is determined by a complex regulatory network of co-acting factors affecting the structure of the chromatin into which the gene is embedded. While significant changes of the transcriptome occur during cell differentiation in apicomplexan parasites, basic mechanisms controlling gene expression are still unknown. Recent studies support and expand the concept of the chromatin environment being key factor for the control of transcriptional activity in these lower eukaryotes organisms. Here, we review recent advances in the field of epigenetic gene regulation in Toxoplasma gondii, the model apicomplexan.
Key words: Apicomplexa / Toxoplasma gondii / chromatin / transcription / epigenetics
© PRINCEPS Editions, Paris, 2008, transferred to Société Française de Parasitologie
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