Volume 8, june 2001Xth International Conference on Trichinellosis (20-24 august 2000)
|Page(s)||S188 - S190|
|Published online||17 September 2014|
Xth ICT, August 2000
Improving bioavailability and anthelmintic activity of albendazole by preparing albendazole-cyclodextrin complexes
Departmento de Parasitología y Facultad de Farmacia, Universidad Complutense, Spain
2 Departmento de Parasitología y Facultad de Farmacia, Universidad Complutense y Departamento de Farmacia y Tecnología Farmaceutica. Facultad de Farmacia, Universidad Complutense, Spain.
The bioavailability and anthelmintic activity of albendazole-cyclodextrin complexes (ABZ-CDC) compared to albendazole suspensions in carboxymethylcellulose (ABZ-CMC) was assessed in a mouse model for Trichinella infections. Swiss CD-1 mice experimentally infected with T. spiralis were treated with both formulations against enteral (adult worms) and parenteral (migrating and encysted larvae). Oral bioavailability was assessed in age matched mice treated with 50 mg/kg of both formulations. The anthelmintic effects and plasma concentration of the active metabolite albendazole-sulphoxide (ABZSO) enantiomer (–) were significantly increased following administration of ABZ-CDC in relation to ABZ-CMC.
Key words: albendazole / bioavailability / Trichinella / cyclodextrins
© PRINCEPS Editions, Paris, 2001, transferred to Société Française de Parasitologie
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