Xth ICT, August 2000

A follow-up study of the human class and subclass antibody response developed against the adult stage of Trichinella spiralis

¹ Immunology Department, Escuela Nacional de Ciencias Biológicas, I.P.N. Apdo. Postal CON-238. Mexico, D.F. c.p. 06400 Mexico.
² Hospital General de Zona No. 27, I.M.S.S. Eje Central Lázaro Cárdenas No. 445, Mexico, D.F. 06900 Mexico.

^* Correspondence : M Sc María del Rosario Chapa Ruiz. Apdo. Postal CON-238. Mexico, D.F. c.p. 06400 Mexico. Fax : (5) 729-6000 ext. 62489 - E-mail : mchapa@redipn.ipn.mx

Abstract

We report the analysis by ELISA of class and subclass antibody response against a total soluble extract from T. spiralis adult stage (TSEA) during a year after the infection in 17 symptomatic trichinellosis patients (Sl) and five asymptomatic individual (Al) involved in an outbreak of trichinellosis occurred in the State of Mexico. Serum samples from 20 healthy individuals (Hl) and 24 patients with other parasitosis were included as control. All Sl showed a polyisotypic antibody response against the TSE-A, during the infection. Higher response of lgA, lgE, lgM were detected in Sl during the acute phase of the infection, but only IgE remained at high levels all along the infection. None or a lower reactivity against TSE-A was observed in sera from Al and from Hl. Some patients with trichuriosis and ascariosis showed a higher cross-reactivity against TSE-A when lgG and their subclasses were analyzed.