Xth ICT, August 2000

Clinical appraisal of patients and detection of serum antibodies by ELISA and CIA tests in late periods of Trichinella sp. invasion

¹ Clinic of Parasitic and Tropical Diseases, University of Medical Sciences, Przybyszewskiego 49, Poznan, Poland.
² Dipartimento di Patologia sperimentale, B.M.I.E., Sez Patologia Generale, Via Roma 55, Pisa, Italy.
³ I.Z.S. dell'Umbria e delle Marche, Via Salvemini 1, Perugia, Italy.

^* Correspondence : W. Kocieçka. Tél.: +48 618691609 - Fax : +48 618671232.

Abstract

Results of our studies using ELISA and competitive inhibition assay (CIA) tests fully confirmed the previously experienced trichinellosis and reflected persistent stimulation of antibody production due to the antigen release from Trichinella larvae, which had survived longer and undergone gradual destruction in the muscles. The studies proved that the tests complement each other, yielding concordant results in 86.7 % of cases. Due to its higher specificity, the CIA test can help in interpreting pathological signs/symptoms and in evaluating humoral response activity at late and distant in time periods following the invasion.