Volume 8, june 2001Xth International Conference on Trichinellosis (20-24 august 2000)
|Page(s)||S110 - S113|
|Published online||17 September 2014|
Xth ICT, August 2000
Mucosal responses to infection with Trichinella spiralis in mice
School of Life and Environmental Sciences and
2 School of Medical and Surgical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
* D. Wakelin. Tel.: (115) 9513232 - Fax : (115) 9513252. E-mail : D.Wakelin@nottingham.ac.uk
Infections with T. spiralis in mice elicit strong inflammatory responses. The nature and control of these responses, and their relationship to the process of worm expulsion, have been debated for many years. Many components of inflammation are, like worm expulsion, T cell-dependent, but some are not. The paper describes novel observations on Paneth cell responses to infection in immunologically normal mice and in a variety of T cell-deficient mice. Responses occurred normally in nu/nu and scid/scid mice but not in β/δ knock out mice incapable of generating cells with functional TCR. However all of these mice failed to expel worms in the pattern seen in immunologically normal controls. These data are incorporated into a discussion of the causal relevance of intestinal inflammatory changes to the process of worm expulsion.
Key words: Trichinella spiral / intestine / worm expulsio / mucosa / epithelium / inflammation / mast cells / goblet cells / Paneth cells / T cells / cytokines
© PRINCEPS Editions, Paris, 2001, transferred to Société Française de Parasitologie
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.