Volume 1, Number 1S, March 19943rd CEC Filariasis Network Meeting (Lisbon -IHMT, 4-7 September 1993)
|Page(s)||S27 - S28|
|Published online||30 September 2014|
Ivermectin levels vary in tissues and species
University of Nigeria Teaching Hospital, PMB 1129 Enugu, Nigeria.
Ivermectin (IVM) is high in faeces, not found in urine but low in skin, saliva and breastmilk of man. Plasma levels vary according to species. Binding to plasma proteins varies also. Resistance of some farm animal nematodes to the avermectins have been reported. A small percentage of patients show poor reduction in skin mf after yearly treatment with ivermectin. We suggest that tissue bioavailability of free drug must be ascertained before interpreting animal models and chemotherapy programs.
Key words: ivermectin / chemotherapy / resistance / bioavailability / filariasis / onchocerciasis
© PRINCEPS Editions, Paris, 1994, transferred to Société Française de Parasitologie
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