Issue |
Ann. Parasitol. Hum. Comp.
Volume 68, Number 4, 1993
|
|
---|---|---|
Page(s) | 176 - 181 | |
DOI | https://doi.org/10.1051/parasite/1993684176 | |
Published online | 12 August 2016 |
Mémoire
Onchocerca-like lesions induced by the filarioid nematode cercopithifilaria johnstoni, in its natural hosts and in the laboratory rat1
Lésions de type onchocerquien induites par la filaire Cercopithifilaria johnstoni chez ses hôtes naturels et chez le rat blanc
1
Unité d’Anatomie et de Cytologie Pathologiques, Hôpital Saint-Michel, 33, rue Olivier-de-Serres, F 75015 Paris, France.
2
CSIRO, Division of Wildlife and Ecology, PO Box 84, Lyneham, ACT 2602, Australia.
3
Laboratoire de Biologie Parasitaire, Protistologie, Helminthologie, 61, rue Buffon, 75231 Paris Cedex 05, France.
Accepted: 1 March 1991
Histo-pathological analysis of the eyes, ears, skin and associated skeletal muscles of the back of 14 animals infected with a fila- rioid worm with dermal microfilariae, Cercopithifilaria johnstoni: seven Rattus fuscipes, of which four were naturally infected, two marsupials, Perameles nasuta and Isoodon macrourus, and five R. norvegicus.
This filarioid nematode induces skin and eye lesions in all the infected animals. These lesions are similar to those described earlier with other filarioid species with dermal microfilariae, such as Monanema martini and Onchocerca volvulus; the pathogeny is similar: microfilariae live inside the lymphatic vessels and their accidental exit gives rise to a localized inflammatory reaction leading to fibrosis.
C. johnstoni is particularly interesting because it may be adapted to the laboratory rat, and because the ocular lesions are severe.
Résumé
Analyse anatomo-pathologique des yeux, des lobes auriculaires et de l’aponévrose dorsale de 14 animaux parasités par la filaire à microfilaires dermiques Cercopithifilaria johnstoni : 7 Rattus fuscipes, dont quatre naturellement infestés, 5 R. norvegicus, et deux marsupiaux, Perameles nasuta et Isoodon macrourus.
Comme pour toutes les filaires à microfilaires dermiques déjà étudiées et comme pour O. volvulus, l’espèce détermine chez tous les animaux parasités des lésions dermiques et oculaires. Ici encore, la pathogénie réside essentiellement dans le fait que les microfilaires, situées normalement dans les lymphatiques, déterminent lorsqu’elles en sortent un processus inflammatoire local puis une sclérose cicatricielle.
C. johnstoni est particulièrement intéressant parce qu’il est adaptable au rat blanc, et parce que les lésions oculaires sont intenses.
Key words: Skin-dwelling Microfilariae / Cercopithifilaria johnstoni / Rattus fuscipes / Laboratory Rat / Marsupials / Histo-pathology / Ocular Lesions / Skin Lesions / Human Onchocerciasis
Mots clés : Microfilaires dermiques / Cercopithifilaria johnstoni / Rattus fuscipes / Rat Blanc / Marsupiaux / Anatomo-pathologie / Lésions oculaires / Lésions dermiques / Onchocercose humaine
This investigation was supported by the Science and Technology for Development Programme of the European Community, Contract n° TS2-0067-F, and by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, ID n° 900535.
This work was conducted in accordance with the NHMRC/CSIRO Code of Practice for the care and use of animals in research in Australia.
© Masson, Paris 1993, transferred to Société Française de Parasitologie
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