| Issue |
Ann. Parasitol. Hum. Comp.
Volume 50, Number 4, 1975
|
|
|---|---|---|
| Page(s) | 461 - 468 | |
| DOI | https://doi.org/10.1051/parasite/1975504461 | |
| Published online | 11 October 2017 | |
Mémoire
Cyclic AMP phosphodiesterase activity in Fasciola hepatica (L.) homogenates(*)
Activité de l’AMP cyclique phosphodiestérase dans les homogénats de Fasciola hepatica (L.)
Istituto di Parassitologia, Facoltà di Medicina Veterinaria dell’Università degli Studi di Milano, Via Celoria n° 10, Milano, Italia.
The authors have studied the behaviour of cyclic 3',5'-AMP phosphodiesterase in the 2,000 g supernatant of the Fasciola hepatica homogenate, under basal conditions and after addition of various substances. Dopamine remarkably inhibits the enzyme activity, imidazole causes a strong activation, while serotonin, theophylline, PGE1, and PGF2α appear to be ineffective.
Résumé
On a considéré l’activité in vitro de la 3',5'-AMP cyclique phosphodiesterase dans les surnageants obtenus par centrifugation à 2 000 g des homogénats de Fasciola hepatica bruts ou après addition de différentes substances. La dopamine provoque une inhibition marquée de cette activité enzymatique, l’imidazole cause une forte activation, tandis que la sérotonine, la théophylline, la PGE1 et la PGF2α ne montrent aucun effet appréciable.
© Masson, Paris 1975, transferred to Société Française de Parasitologie
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