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Genome-wide transcriptome analysis of Echinococcus multilocularis larvae and germinative cell cultures reveals genes involved in parasite stem cell function
Michaela Herz, Magdalena Zarowiecki, Leonie Wessels, Katharina Pätzel, Ruth Herrmann, Christiane Braun, Nancy Holroyd, Thomas Huckvale, Monika Bergmann, Markus Spiliotis, Uriel Koziol, Matthew Berriman and Klaus Brehm Frontiers in Cellular and Infection Microbiology 14 (2024) https://doi.org/10.3389/fcimb.2024.1335946
Effect of Hydroxyurea on Morphology, Proliferation, and Protein Expression on Taenia crassiceps WFU Strain
Diana G. Rios-Valencia, Karel Estrada, Arturo Calderón-Gallegos, Rocío Tirado-Mendoza, Raúl J. Bobes, Juan P. Laclette and Margarita Cabrera-Bravo International Journal of Molecular Sciences 25(11) 6061 (2024) https://doi.org/10.3390/ijms25116061
Echinococcus multilocularis delta/notch signalling components are expressed in post-mitotic cells
In Vitro Activities of Dithiocarbamate Derivatives against Echinococcus multilocularis Metacestode Vesicles
Marc Kaethner, Georg Rennar, Tom Gallinger, Tobias Kämpfer, Andrew Hemphill, Patrick Mäder, Ana Luque-Gómez, Martin Schlitzer and Britta Lundström-Stadelmann Tropical Medicine and Infectious Disease 8(12) 517 (2023) https://doi.org/10.3390/tropicalmed8120517
Watch-and-wait approach for inactive echinococcal cysts: scoping review update since the issue of the WHO-IWGE Expert Consensus and current perspectives
Establishment and application of unbiased in vitro drug screening assays for the identification of compounds against Echinococcus granulosus sensu stricto
Marc Kaethner, Matías Preza, Tobias Kaempfer, Pascal Zumstein, Claudia Tamponi, Antonio Varcasia, Andrew Hemphill, Klaus Brehm, Britta Lundström-Stadelmann and Cristian A. Alvarez Rojas PLOS Neglected Tropical Diseases 17(8) e0011343 (2023) https://doi.org/10.1371/journal.pntd.0011343
Establishment of a secondary infection laboratory model of Echinococcus shiquicus metacestode using BALB/c mice and Mongolian jirds (Meriones unguiculatus)
Yantao Wu, Li Li, Fuling Xu, Hongbin Yan, John Asekhaen Ohiolei, Nigus Abebe Shumuye, Xiaofeng Nian, Wenhui Li, Nianzhang Zhang, Baoquan Fu and Wanzhong Jia Parasitology 1 (2023) https://doi.org/10.1017/S0031182023000604
Cellular and molecular basis associated with metacestode proliferation in subarachnoid neurocysticercosis
Tania Rozario, James J. Collins and Phillip A. Newmark Current Topics in Developmental Biology, Emerging Model Systems in Developmental Biology 147 345 (2022) https://doi.org/10.1016/bs.ctdb.2021.12.015
Transcriptional effects of electroporation on Echinococcus multilocularis primary cell culture
Matías Gastón Pérez, Natalia Rego, Markus Spiliotis, Klaus Brehm and Mara Cecilia Rosenzvit Parasitology Research 121(4) 1155 (2022) https://doi.org/10.1007/s00436-022-07427-5
The combination of carvacrol and albendazole enhanced the efficacy of monotherapy in experimental alveolar echinococcosis
Metformin Suppresses Development of the Echinococcus multilocularis Larval Stage by Targeting the TOR Pathway
Julia A. Loos, Valeria A. Dávila, Klaus Brehm and Andrea C. Cumino Antimicrobial Agents and Chemotherapy 64(9) (2020) https://doi.org/10.1128/AAC.01808-19
In Vitro
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In Vivo
Efficacies of the EGFR/MEK/ERK Signaling Inhibitors in the Treatment of Alveolar Echinococcosis
Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis
Britta Lundström-Stadelmann, Reto Rufener and Andrew Hemphill International Journal for Parasitology: Drugs and Drug Resistance 13 121 (2020) https://doi.org/10.1016/j.ijpddr.2020.06.002
Albendazole solid dispersions against alveolar echinococcosis: a pharmacotechnical strategy to improve the efficacy of the drug
EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development
Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin