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New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids
Ferroquine and its derivatives: New generation of antimalarial agents
Waseem A. Wani, Ehtesham Jameel, Umair Baig, Syed Mumtazuddin and Lee Ting Hun European Journal of Medicinal Chemistry 101 534 (2015) https://doi.org/10.1016/j.ejmech.2015.07.009
Chloroquine-based hybrid molecules as promising novel chemotherapeutic agents
Timothy N. C. Wells, Rob Hooft van Huijsduijnen and Wesley C. Van Voorhis Nature Reviews Drug Discovery 14(6) 424 (2015) https://doi.org/10.1038/nrd4573
Vesicular disruption of lysosomal targeting organometallic polyarginine bioconjugates
Redox-active cationic organoiron complex: a promising lead structure for developing antimicrobial agents with activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium
Alaa S. Abd-El-Aziz, Christian Agatemor, Nola Etkin, David P. Overy and Russell G. Kerr RSC Advances 5(105) 86421 (2015) https://doi.org/10.1039/C5RA16613F
Antibacterial and Antiparasitic Activity of Manganese(I) Tricarbonyl Complexes with Ketoconazole, Miconazole, and Clotrimazole Ligands
Synthesis and tripanocidal activity of ferrocenyl and benzyl diamines against Trypanosoma brucei and Trypanosoma cruzi
Angela Maria Arenas Velásquez, Acácio Ivo Francisco, Andréa Akiko Nakaima Kohatsu, Flavia Alves de Jesus Silva, Danilo Fernando Rodrigues, Rafaela Gomes da Silva Teixeira, Bruna Galdorfini Chiari, Maria Gabriela José de Almeida, Vera Lucia Borges Isaac, Maria D. Vargas and Regina Maria Barretto Cicarelli Bioorganic & Medicinal Chemistry Letters 24(7) 1707 (2014) https://doi.org/10.1016/j.bmcl.2014.02.046
7‐Chloroquinoline–isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation
Raghu Raj, Christophe Biot, Séverine Carrère‐Kremer, Laurent Kremer, Yann Guérardel, Jiri Gut, Philip J. Rosenthal, Delphine Forge and Vipan Kumar Chemical Biology & Drug Design 83(5) 622 (2014) https://doi.org/10.1111/cbdd.12273
Faustine Dubar and Christophe Biot 141 (2014) https://doi.org/10.1002/9783527673438.ch05
Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells
Synthesis and Evaluation of Antimalarial Properties of Novel 4‐Aminoquinoline Hybrid Compounds
Gillian M. Fisher, Rajendra P. Tanpure, Antoine Douchez, Katherine T. Andrews and Sally‐Ann Poulsen Chemical Biology & Drug Design 84(4) 462 (2014) https://doi.org/10.1111/cbdd.12335
Interaction of a Biguanide Compound with Membrane Model Interface Systems: Probing the Properties of Antimalaria and Antidiabetic Compounds
Nuttaporn Samart, Cheryle N. Beuning, Kenneth J. Haller, Chris D. Rithner and Debbie C. Crans Langmuir 30(29) 8697 (2014) https://doi.org/10.1021/la501600s
In vitro and in vivo antischistosomal activity of ferroquine derivatives
Jennifer Keiser, Mireille Vargas, Riccardo Rubbiani, Gilles Gasser and Christophe Biot Parasites & Vectors 7(1) 424 (2014) https://doi.org/10.1186/1756-3305-7-424
1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: Synthesis and antimalarial evaluation
The antimalarial ferroquine is an inhibitor of hepatitis C virus
Thibaut Vausselin, Noémie Calland, Sandrine Belouzard, Véronique Descamps, Florian Douam, François Helle, Catherine François, Dimitri Lavillette, Gilles Duverlie, Ahmed Wahid, Lucie Fénéant, Laurence Cocquerel, Yann Guérardel, Czeslaw Wychowski, Christophe Biot and Jean Dubuisson Hepatology 58(1) 86 (2013) https://doi.org/10.1002/hep.26273
Analysis of the Mechanism of Action of Potent Antibacterial Hetero-tri-organometallic Compounds: A Structurally New Class of Antibiotics
Michaela Wenzel, Malay Patra, Christoph Helmut Rudi Senges, et al. ACS Chemical Biology 8(7) 1442 (2013) https://doi.org/10.1021/cb4000844
In Vitro
Effects of Novel Ruthenium Complexes in Neospora caninum and Toxoplasma gondii Tachyzoites
Fabienne Barna, Karim Debache, Carsten A. Vock, Tatiana Küster and Andrew Hemphill Antimicrobial Agents and Chemotherapy 57(11) 5747 (2013) https://doi.org/10.1128/AAC.02446-12
Di- and Trinuclear Ruthenium-, Rhodium-, and Iridium-Functionalized Pyridyl Aromatic Ethers: A New Class of Antiparasitic Agents
Pharmacokinetics of Ferroquine, a Novel 4-Aminoquinoline, in Asymptomatic Carriers of Plasmodium falciparum Infections
Christian Supan, Ghyslain Mombo-Ngoma, Matthias P. Dal-Bianco, et al. Antimicrobial Agents and Chemotherapy 56(6) 3165 (2012) https://doi.org/10.1128/AAC.05359-11
Iminosugar–ferrocene conjugates as potential anticancer agents