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Table 2

Risk factors for single mutations in the Pfdhfr gene.

Variable Pfdhfr N51I mutation Pfdhfr C59R mutation Pfdhfr S108N mutation
cORa (95% CI) aORb (95% CI) p cORa (95% CI) aORb (95% CI) p cORa (95% CI) aORb (95% CI) p
Age (years)
 ≤ 20 0.9 (0.5–1.7) 0.9 (0.5–1.7) 1.3 (0.7–2.6)
 > 20 1 1 1
Gravidity
 Paucigravidae 1.1 (0.6–2.0) 1.2 (0.6–2.1) 0.642 0.9 (0.8–2.7) 1.0 (0.5–1.8) 0.961 1.5 (0.8–2.7) 1.6 (0.8–2.9) 0.163
 Multigravidae 1 1 1 1 1 1
Gestational age
 1st trimester 1 1 1 1 1 1
 2nd and 3rd trimesters 2.1 (1.14.0) 2.1 (1.14.0) 0.028 1.7 (0.9–3.4) 1.7 (0.9–3.4) 0.109 1.7 (0.9–3.3) 1.7 (0.9–3.5) 0.072

aCrude odd ratio; bAdjusted odd ratio.

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