Open Access
Table 2
Risk factors for single mutations in the Pfdhfr gene.
| Variable | Pfdhfr N51I mutation | Pfdhfr C59R mutation | Pfdhfr S108N mutation | ||||||
|---|---|---|---|---|---|---|---|---|---|
| cORa (95% CI) | aORb (95% CI) | p | cORa (95% CI) | aORb (95% CI) | p | cORa (95% CI) | aORb (95% CI) | p | |
| Age (years) | |||||||||
| ≤ 20 | 0.9 (0.5–1.7) | – | – | 0.9 (0.5–1.7) | – | – | 1.3 (0.7–2.6) | – | – |
| > 20 | 1 | – | – | 1 | – | – | 1 | – | – |
| Gravidity | |||||||||
| Paucigravidae | 1.1 (0.6–2.0) | 1.2 (0.6–2.1) | 0.642 | 0.9 (0.8–2.7) | 1.0 (0.5–1.8) | 0.961 | 1.5 (0.8–2.7) | 1.6 (0.8–2.9) | 0.163 |
| Multigravidae | 1 | 1 | – | 1 | 1 | – | 1 | 1 | – |
| Gestational age | |||||||||
| 1st trimester | 1 | 1 | 1 | 1 | 1 | 1 | |||
| 2nd and 3rd trimesters | 2.1 (1.1–4.0) | 2.1 (1.1–4.0) | 0.028 | 1.7 (0.9–3.4) | 1.7 (0.9–3.4) | 0.109 | 1.7 (0.9–3.3) | 1.7 (0.9–3.5) | 0.072 |
aCrude odd ratio; bAdjusted odd ratio.
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