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Table 4
Proteins of Toxoplasma gondii RH strain identified by LC-MS/MS for the fourth IgM triplet spot of interest (spot 24) (ND: not detected).
| Protein name | Known or predicted function | Location | Accession | Organism | Molecular weight (Da) | Peptide count on protein profile No. 1 | Peptide count on protein profile No. 2 |
|---|---|---|---|---|---|---|---|
| Heat Shock Protein (HSP) | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system | TGME49_chrXII:5582774-5587740(−) | TGME49_251780 | Toxoplasma_gondii_ME49 | 78251 | 51 | 45 |
| Chaperonin protein BiP | Molecular chaperone involved in protein folding and exit from the endoplasmic reticulum | TGME49_chrXI:2225378-2228753(−) | TGME49_311720 | Toxoplasma_gondii_ME49 | 73253 | 33 | 30 |
| Cytosolic tRNA-Ala synthetase | Cytosolic protein involved in the aminoacylation of tRNA during proteins synthesis | TGME49_chrXII:862344-876041(−) | TGME49_219540 | Toxoplasma_gondii_ME49 | 139516 | 29 | 21 |
| Vacuolar ATP synthase subunit A, putative | Proton-transporting ATP synthase activity contributing to endomembrane compartments acidification, organelle maturation, and intracellular pH regulation | TGME49_chrVIIb:4315661-4325274(−) | TGME49_256970 | Toxoplasma_gondii_ME49 | 68122 | 28 | 17 |
| Tryptophanyl-tRNA synthetase (TrpRS2) | Apicoplast protein involved in the aminoacylation of tRNA during proteins synthesis | TGME49_chrIX:2473710-2478137(+) | TGME49_288360 | Toxoplasma_gondii_ME49 | 77058 | 24 | 10 |
| Chaperonin cpn60, putative | ATP-dependent chaperone involved in protein folding | TGME49_chrVI:1335457-1339036(+) | TGME49_240600 | Toxoplasma_gondii_ME49 | 72237 | 23 | 11 |
| Alveolin domain containing intermediate filament IMC1 (ALV1) | Inner membrane complex protein associated with the membrane cytoskeleton of Toxoplasma gondii, involved in maintaining parasite morphology and motility | TGME49_chrVIII:1516857-1519632(+) | TGME49_231640 | Toxoplasma_gondii_ME49 | 69596 | 14 | 12 |
| Heat Shock Protein 70 (HSP70) | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system (modulation of nitric oxide production and reduction of macrophages phagocytosis capacity) | TGME49_chrVIII:3289396-3291420(−) | TGME49_273760 | Toxoplasma_gondii_ME49 | 72880 | 13 | 12 |
| Hypothetical protein | No function described | TGME49_chrVIII:2878595-2883425(−) | TGME49_233890 | Toxoplasma_gondii_ME49 | 73697 | 11 | 7 |
| Aconitate hydratase ACN/IRP | Mitochondrial/apicoplast enzyme involved in the energy metabolism of Toxoplasma gondii (Krebs cycle) and regulation of host immune system (modulation of nitric oxide production) | TGME49_chrX:1400984-1408155(−) | TGME49_226730 | Toxoplasma_gondii_ME49 | 114885 | 10 | 3 |
| Cell Division protein C48CY (CDC48CY) | AAA + ATPase protein involved in protein unfolding, degradation, membrane fusion, and regulation of turnover during cell cycle transitions | TGME49_chrVIII:3664539-3673736(−) | TGME49_273090 | Toxoplasma_gondii_ME49 | 89397 | 7 | 4 |
| FUSE-Binding Protein 2 / KH-type splicing regulatory protein (FUBP2) | Protein involved in transcriptional regulation and post-transcriptional control, including mRNA splicing, stabilization, and localization | TGME49_chrXI:5969861-5973900(−) | TGME49_216670 | Toxoplasma_gondii_ME49 | 100094 | 7 | 1 |
| Toxolysin 4 (TLN4) | Member of the M16A metalloprotease family, involved in Toxoplasma gondii egress from host cells and maturation of microneme proteins | TGME49_chrVIIa:903405-917753(+) | TGME49_206510 | Toxoplasma_gondii_ME49 | 246741 | 6 | ND |
| ATPase, AAA family protein | AAA + ATPase family protein involved in protein unfolding, degradation, membrane fusion, and regulation of turnover during cell cycle transitions | TGME49_chrX:4365489-4372954(−) | TGME49_234420 | Toxoplasma_gondii_ME49 | 66807 | 5 | 1 |
| RNA recognition motif-containing protein | Protein involved in various aspects of RNA metabolism including splicing, transport, stability, and translation | TGME49_chrIX:4405615-4411375(+) | TGME49_291930 | Toxoplasma_gondii_ME49 | 73118 | 5 | 1 |
| SAG-related sequence SRS29B (SRS29B) | Surface protein involved in host cell attachment | TGME49_chrVIII:2664481-2665491(+) | TGME49_233460 | Toxoplasma_gondii_ME49 | 34732 | 4 | 2 |
| Actin 1 (ACT1) | Glideosome protein involved in gliding movement of Toxoplasma gondii, organelles distribution during cell division and secretory vesicles movement within the parasite | TGME49_chrIb:998462-1000024(+) | TGME49_209030 | Toxoplasma_gondii_ME49 | 41908 | 4 | 2 |
| Heat Shock Protein 90 (HSP90) | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system | TGME49_chrIX:2483404-2487798(+) | TGME49_288380 | Toxoplasma_gondii_ME49 | 81933 | 4 | 1 |
| D-3-phosphoglycerate dehydrogenase | Enzyme contributing to amino acid metabolism and providing precursors for nucleotide and lipid biosynthesis | TGME49_chrVI:939130-947919(−) | TGME49_239820 | Toxoplasma_gondii_ME49 | 65194 | 4 | 1 |
| Dynamin-Related Protein B (DRPB) | Member of the dynamin superfamily of GTPases involved in membrane remodeling processes | TGME49_chrIb:1689989-1700172(+) | TGME49_321620 | Toxoplasma_gondii_ME49 | 95931 | 4 | 1 |
| Microneme protein 1 (MIC1) | Protein secreted from apical micronemes during initial stages of host cell entry, forming a complex with MIC4 and MIC6 to mediate adhesion to host receptors | TGME49_chrIX:4395345-4397688(−) | TGME49_291890 | Toxoplasma_gondii_ME49 | 48629 | 4 | ND |
| EMP24/GP25L/p24 family protein | Family of proteins involved in protein transport between endoplasmic reticulum, Golgi, and specialized organelles (micronemes or rhoptries) | TGME49_chrXI:1568699-1573498(+) | TGME49_310750 | Toxoplasma_gondii_ME49 | 64977 | 3 | 1 |
| Hypothetical protein | No function described | TGME49_chrVIIa:3523795-3527924(−) | TGME49_202200 | Toxoplasma_gondii_ME49 | 87043 | 3 | ND |
| Protein disulfide isomerase | Endoplasmic reticulum enzyme involved in protein folding and redox homeostasis contributing to maturation and quality control of secretory and membrane proteins | TGME49_chrIV:1626551-1628375(+) | TGME49_211680 | Toxoplasma_gondii_ME49 | 52802 | 2 | 1 |
| Heat Shock Protein 90, putative | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system | TGME49_chrVI:3356828-3362144(+) | TGME49_244560 | Toxoplasma_gondii_ME49 | 96823 | 2 | ND |
| Ubiquitin specific protease 39 isoform 2, putative | Protease involved in spliceosome assembly, regulation of pre-mRNA splicing and proper gene expression | TGME49_chrIa:840906-848857(+) | TGME49_294360 | Toxoplasma_gondii_ME49 | 64190 | 2 | ND |
| Domain K- type RNA binding proteins family protein | Proteins involved in post-transcriptional regulation, including RNA stability, splicing, transport, and translation | TGME49_chrX:5186140-5192433(+) | TGME49_235930 | Toxoplasma_gondii_ME49 | 64265 | 2 | ND |
| Apical Membrane Antigen 1 (AMA1) | Microneme protein secreted onto the parasite surface during host cell invasion, plays a key role in moving junction formation by interacting with rhoptry neck proteins | TGME49_chrVIIb:4948067-4952962(+) | TGME49_255260 | Toxoplasma_gondii_ME49 | 63021 | 2 | ND |
| Alpha Tubulin A1 (TUBA1) | Microtubule-associated protein involved in maintaining Toxoplasma gondii’s shape, intracellular transport, and apical complex organization | TGME49_chrXI:5274572-5276593(+) | TGME49_316400 | Toxoplasma_gondii_ME49 | 50114 | 2 | ND |
| Hypothetical protein | No function described | TGME49_chrXI:4609959-4617338(−) | TGME49_315270 | Toxoplasma_gondii_ME49 | 84600 | 2 | ND |
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