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Table 2
Proteins of Toxoplasma gondii RH strain identified by LC-MS/MS for the second IgM triplet spot of interest (spot 22) (ND: not detected).
| Protein name | Known or predicted function | Location | Accession | Organism | Molecular weight (Da) | Peptide count on protein profile No. 1 | Peptide count on protein profile No. 2 |
|---|---|---|---|---|---|---|---|
| Heat Shock Protein (HSP) | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system | TGME49_chrXII:5582774-5587740(−) | TGME49_251780 | Toxoplasma_gondii_ME49 | 78251 | 46 | 60 |
| Heat Shock Protein 70 (HSP70) | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system (modulation of nitric oxide production and reduction of macrophages phagocytosis capacity) | TGME49_chrVIII:3289396-3291420(−) | TGME49_273760 | Toxoplasma_gondii_ME49 | 72880 | 43 | 42 |
| Heat Shock Protein 90 (HSP90) | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system | TGME49_chrIX:2483404-2487798(+) | TGME49_288380 | Toxoplasma_gondii_ME49 | 81933 | 27 | 25 |
| Chaperonin protein BiP | Molecular chaperone involved in protein folding and exit from the endoplasmic reticulum | TGME49_chrXI:2225378-2228753(−) | TGME49_311720 | Toxoplasma_gondii_ME49 | 73253 | 26 | 40 |
| Alveolin domain containing intermediate filament IMC1 (ALV1) | Inner membrane complex protein associated with the membrane cytoskeleton of Toxoplasma gondii, involved in maintaining parasite morphology and motility | TGME49_chrVIII:1516857-1519632(+) | TGME49_231640 | Toxoplasma_gondii_ME49 | 69596 | 15 | 25 |
| Cytosolic tRNA-Ala synthetase | Cytosolic protein involved in the aminoacylation of tRNA during proteins synthesis | TGME49_chrXII:862344-876041(−) | TGME49_219540 | Toxoplasma_gondii_ME49 | 139516 | 6 | 7 |
| Vacuolar ATP synthase subunit A, putative | Proton-transporting ATP synthase activity contributing to endomembrane compartments acidification, organelle maturation, and intracellular pH regulation | TGME49_chrVIIb:4315661-4325274(−) | TGME49_256970 | Toxoplasma_gondii_ME49 | 68122 | 4 | 13 |
| Protease inhibitor 1 (PI1) | Protein involved in modulation of protease activity by inhibiting cysteine or serine proteases | TGME49_chrXII:1832043-1834438(−) | TGME49_217430 | Toxoplasma_gondii_ME49 | 47782 | 4 | 3 |
| Nuclear Factor 4 (NF4) | Putative transcription factor regulating gene expression | TGME49_chrVIIa:1293654-1297697(+) | TGME49_205580 | Toxoplasma_gondii_ME49 | 51221 | 4 | ND |
| Hypothetical protein | No function described | TGME49_chrVIII:2878595-2883425(−) | TGME49_233890 | Toxoplasma_gondii_ME49 | 73697 | 3 | 7 |
| Toxolysin 4 (TLN4) | Member of the M16A metalloprotease family, involved in Toxoplasma gondii egress from host cells and maturation of microneme proteins | TGME49_chrVIIa:903405-917753(+) | TGME49_206510 | Toxoplasma_gondii_ME49 | 246741 | 3 | 6 |
| Tryptophanyl-tRNA synthetase (TrpRS2) | Apicoplast protein involved in the aminoacylation of tRNA during proteins synthesis | TGME49_chrIX:2473710-2478137(+) | TGME49_288360 | Toxoplasma_gondii_ME49 | 77058 | 3 | 6 |
| Lysine-tRNA ligase | Enzyme ensuring the fidelity of lysine incorporation into nascent polypeptides, playing a key role in protein synthesis and cellular function | TGME49_chrVIIa:1202972-1207953(+) | TGME49_205710 | Toxoplasma_gondii_ME49 | 74395 | 3 | ND |
| SAG-related sequence SRS29B (SRS29B) | Surface protein involved in host cell attachment | TGME49_chrVIII:2664481-2665491(+) | TGME49_233460 | Toxoplasma_gondii_ME49 | 34732 | 2 | 2 |
| Actin 1 (ACT1) | Glideosome protein involved in gliding movement of Toxoplasma gondii, organelles distribution during cell division and secretory vesicles movement within the parasite | TGME49_chrIb:998462-1000024(+) | TGME49_209030 | Toxoplasma_gondii_ME49 | 41908 | 2 | 2 |
| Hypothetical protein | No function described | TGME49_chrXI:4609959-4617338(−) | TGME49_315270 | Toxoplasma_gondii_ME49 | 84600 | 2 | 2 |
| Histone lysine methyltransferase, SET, putative | Histone-lysine N-methyltransferase activity involved in epigenetic regulation | TGME49_chrVIIb:1042995-1044560(−) | TGME49_262750 | Toxoplasma_gondii_ME49 | 53633 | 2 | 1 |
| Alveolin domain containing intermediate filament IMC4 (ALV4) | Inner membrane complex protein contributing to the cytoskeletal scaffold that provides mechanical strength and structural support to the parasite | TGME49_chrVIII:1513141-1515301(−) | TGME49_231630 | Toxoplasma_gondii_ME49 | 50172 | 2 | 1 |
| Ulp1 protease family, C-terminal catalytic domain-containing protein | Enzyme involved in the maturation of ubiquitin-like proteins such as SUMO, contributing to post-translational modification regulation | TGME49_chrIX:1711745-1725039(+) | TGME49_265190 | Toxoplasma_gondii_ME49 | 329629 | 2 | 1 |
| Inner Membrane Complex protein 2A (IMC2A) | Inner membrane complex protein contributing to the structural integrity and organization of the parasite pellicle | TGME49_chrX:520228-525722(−) | TGME49_228170 | Toxoplasma_gondii_ME49 | 170816 | 2 | 1 |
| EMP24/GP25L/p24 family protein | Family of proteins involved in protein transport between endoplasmic reticulum, Golgi, and specialized organelles (micronemes or rhoptries) | TGME49_chrXI:1568699-1573498(+) | TGME49_310750 | Toxoplasma_gondii_ME49 | 64977 | 2 | 1 |
| Chaperonin cpn60, putative | ATP-dependent chaperone involved in protein folding | TGME49_chrVI:1335457-1339036(+) | TGME49_240600 | Toxoplasma_gondii_ME49 | 72237 | ND | 7 |
| Peptidase M16 inactive domain-containing protein | Member of the M16A metalloprotease family, no function described | TGME49_chrX:716364-726488(+) | TGME49_227948 | Toxoplasma_gondii_ME49 | 142764 | ND | 5 |
| Hypothetical protein | No function described | TGME49_chrVIIa:3523795-3527924(−) | TGME49_202200 | Toxoplasma_gondii_ME49 | 87043 | ND | 4 |
| Membrane Occupation and Recognition Nexus protein 2 (MORN2) | No function described, hypothetical role in cytoskeleton organization | TGME49_chrIX:4562922-4564319(+) | TGME49_292120 | Toxoplasma_gondii_ME49 | 49236 | ND | 4 |
| Heat Shock Protein 90, putative | Molecular chaperone involved in protein folding, cellular stress responses, and regulation of host immune system | TGME49_chrVI:3356828-3362144(+) | TGME49_244560 | Toxoplasma_gondii_ME49 | 96823 | ND | 2 |
| Domain K- type RNA binding proteins family protein | Proteins involved in post-transcriptional regulation, including RNA stability, splicing, transport, and translation | TGME49_chrX:5186140-5192433(+) | TGME49_235930 | Toxoplasma_gondii_ME49 | 64265 | ND | 2 |
| Aconitate hydratase ACN/IRP | Mitochondrial/apicoplast enzyme involved in the energy metabolism of Toxoplasma gondii (Krebs cycle) and regulation of host immune system (modulation of nitric oxide production) | TGME49_chrX:1400984-1408155(−) | TGME49_226730 | Toxoplasma_gondii_ME49 | 114885 | ND | 2 |
| D-3-phosphoglycerate dehydrogenase | Enzyme contributing to amino acid metabolism and providing precursors for nucleotide and lipid biosynthesis | TGME49_chrVI:939130-947919(−) | TGME49_239820 | Toxoplasma_gondii_ME49 | 65194 | ND | 2 |
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