Table 2
Efficacy.
| Challenge Day 1 |
Challenge Day 7 |
Challenge Day 14 |
Challenge Day 21 |
Challenge Day 28 |
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | 15 min | 48 h | 72 h | 96 h | 15 min | 48 h | 72 h | 96 h | 15 min | 48 h | 72 h | 96 h | 15 min | 48 h | 72 h | 96 h | 15 min | 48 h | 72 h | 96 h | |
| Sham-dose | AM | 18.9 | 18.7 | 18.7 | 18.1 | 19.1 | 17.9 | 17.9 | 16.4 | 18.6 | 18.6 | 18.3 | 18.1 | 19.0 | 19.0 | 19.0 | 19.0 | 18.4 | 18.4 | 18.4 | 18.3 |
| Prop. | 0.99 | 0.99 | 0.96 | 0.93 | 0.93 | 0.86 | 1.00 | 0.98 | 0.98 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | ||||||
| NexGard Combo | AM | 16.7 | 11.0 | 3.7 | 3.1 | 18.9 | 12.0 | 3.6 | 3.1 | 15.4 | 5.9 | 3.9 | 2.6 | 15.7 | 7.4 | 3.7 | 1.9 | 17.00 | 13.0 | 7.7 | 7.0 |
| Prop. | 0.66 | 0.22 | 0.19 | 0.64 | 0.19 | 0.17 | 0.39 | 0.26 | 0.18 | 0.48 | 0.24 | 0.12 | 0.77 | 0.45 | 0.41 | ||||||
| Efficacy (%) | 33.3 | 78.1 | 80.6 | 31.3 | 79.8 | 80.6 | 61.0 | 74.0 | 81.8 | 51.8 | 76.1 | 88.0 | 23.3 | 54.5 | 58.2 | ||||||
| P-value | 0.0025 | <.0001 | <.0001 | 0.0064 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | <.0001 | 0.0004 | <.0001 | <.0001 | ||||||
AM = arithmetic mean of live fed bedbugs, collected and placed in incubation (15 min), and surviving (48 h, 72 h and 96 h).
Prop. = proportion of live bedbugs relative to the number of bedbugs placed in incubation.
Efficacy (%) = 100 × (Mc – Mt)/Mc, where Mc = Proportion of live, fed bedbugs in the control group at 48 h, 72 h and 96 h, Mt = Proportion of live, fed bedbugs in the treated group at 48 h, 72 h and 96 h, after the 15 min challenge phase.
P-value = One-way ANOVA with a treatment effect.
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