Table 1
(A) Diagnostic performances of Sysmex XN-31 compared to microscopy (thin or thick slides). All the blood samples (357 samples) included were used for this analysis (samples at admission and samples during the follow-up). (B) Diagnostic performances of Sysmex XN-31 compared to microscopy (thin or thick slides), Real-time PCR, LAMP (Meridian) and Rapid Diagnostic Test (CareStart) limited to the samples collected at admission (288 samples).
| Microscopy | LAMP | RDT |
|||||
|---|---|---|---|---|---|---|---|
| Positive | Negative | Positive | Negative | Positive | Negative | ||
| A | |||||||
| XN 31 | Positive | 109 | 4 | 110 | 3 | 111 | 2 |
| Negative | 0 | 244 | 12 | 232 | 10 | 234 | |
| Sensitivity | % (95% CI) | 100 (97.13–100) | 96.16 (93.40–98.92) | 91.74 (88.87–94.37) | |||
| Specificity | % (95% CI) | 98.39 (95.56–100) | 98.72 (95.88–100) | 99.15 (96.30–100) | |||
| PPV | % (95% CI) | 96.46 (93.69–99.22) | 97.35 (94.55–100) | 98.23 (95.41–100) | |||
| NPV | % (95% CI) | 100 (97.13–100) | 95.08 (92.35–97.80) | 95.9 (93.03–98.65) | |||
| X2 | p < 0.001 | p < 0.001 | p < 0.001 | ||||
| B | |||||||
| XN 31 | Positive | 97 | 0 | 96 | 1 | 95 | 2 |
| Negative | 1 | 190 | 5 | 186 | 4 | 187 | |
| Sensitivity | % (95% CI) | 98.98 (96.14–100) | 95.05 (92.32–97.78) | 95.96 (93.21–98.71) | |||
| Specificity | % (95% CI) | 100 (97.13–100) | 99.47 (96.62–100) | 98.94 (96.10–100) | |||
| PPV | % (95% CI) | 100 (97.13–100) | 98.97 (96.13–100) | 97.94 (95.13–100) | |||
| NPV | % (95% CI) | 99.48 (96.62–100) | 97.38 (94.59–100) | 97.91 (95.10–100) | |||
| X2 | p < 0.001 | p < 0.001 | p < 0.001 | ||||
PPV: positive predictive value; NPV: negative predictive value.
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