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Research Article

Table 1

(A) Diagnostic performances of Sysmex XN-31 compared to microscopy (thin or thick slides). All the blood samples (357 samples) included were used for this analysis (samples at admission and samples during the follow-up). (B) Diagnostic performances of Sysmex XN-31 compared to microscopy (thin or thick slides), Real-time PCR, LAMP (Meridian) and Rapid Diagnostic Test (CareStart) limited to the samples collected at admission (288 samples).

Microscopy
LAMP
RDT
PositiveNegativePositiveNegativePositiveNegative
A
XN 31Positive109411031112
Negative02441223210234

Sensitivity% (95% CI)100 (97.13–100)96.16 (93.40–98.92)91.74 (88.87–94.37)
Specificity% (95% CI)98.39 (95.56–100)98.72 (95.88–100)99.15 (96.30–100)
PPV% (95% CI)96.46 (93.69–99.22)97.35 (94.55–100)98.23 (95.41–100)
NPV% (95% CI)100 (97.13–100)95.08 (92.35–97.80)95.9 (93.03–98.65)
X2p < 0.001p < 0.001p < 0.001

B
XN 31Positive970961952
Negative119051864187

Sensitivity% (95% CI)98.98 (96.14–100)95.05 (92.32–97.78)95.96 (93.21–98.71)
Specificity% (95% CI)100 (97.13–100)99.47 (96.62–100)98.94 (96.10–100)
PPV% (95% CI)100 (97.13–100)98.97 (96.13–100)97.94 (95.13–100)
NPV% (95% CI)99.48 (96.62–100)97.38 (94.59–100)97.91 (95.10–100)
X2p < 0.001p < 0.001p < 0.001

PPV: positive predictive value; NPV: negative predictive value.

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