Open Access
Research Article

Table 2

Specificity of individual HAT diagnostic tests and test combinations, performed in parallel or in series.

Diagnostic test Total positive % specificity (95% CI) test negative/HAT freea
rHAT Sero-Strip 42 99.3 (99.0–99.5) 5828/5870
SD-Bioline HAT 419 92.9 (92.2–93.5) 5451/5870
HAT Sero-K-Set 641 89.1 (88.3–89.8) 5229/5870
All RDTs (in parallel) 829 85.9 (85.0–86.7) 5041/5870
Sero-K-Set + rHAT Sero-Strip (parallel) 666 88.7 (87.8–89.4) 5204/5870
HAT Sero-K-Set + SD Bioline (parallel) 807 86.3 (85.4–87.1) 5063/5870
rHAT Sero Strip + SD Bioline HAT (parallel) 453 92.3 (91.6–92.9) 5417/5870
All RDTs (in series) 5 99.9 (99.8–100) 5865/5870
Sero-K-Set + rHAT Sero-Strip (series) 17 99.7 (99.5–99.8) 5853/5870
HAT Sero-K-Set + SD Bioline (series) 253 95.7 (95.1–96.2) 5617/5870
rHAT Sero Strip + SD Bioline HAT (series) 8 99.9 (99.7–99.9) 5862/5870
Trypanolysis 0 100 (99.5–100) 816/816
ELISA/T. b. gambiense 7 99.1 (98.5–99.7) 809/816
a

Denominator of 5870 for RDTs, and 816 (RDT positives only) for both trypanolysis and ELISA/T. b. gambiense; CI: confidence interval.

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