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Table 4
Multivariate analysis of risk factors associated with the occurrence of treatment failures.
| Logistic model | Failure (%) | Odds ratio [CI 95%] | p-value |
|---|---|---|---|
| Half-life (hours) | |||
| < 5 h | 40 (10.4) | 1 | – |
| > 5 h | 6 (21.4) | 3.69 [1.18–10.3] | 0.01 |
| Hemoglobin type | |||
| AA | 40 (6.2) | 1 | – |
| AC | 4 (6.7) | 1.5 [0.21–6.25] | 0.62 |
| AS | 1 (2.1) | 0.54 [0.02–2.94] | 0.56 |
| CC | 1 (20.0) | 11.74 [0.54–104] | 0.04 |
| SC | 0 (0.0) | 0 | 0.99 |
| SS | 0 (0.0) | 0 | 0.99 |
| Gender | |||
| Female | 18 (4.4) | 1 | – |
| Male | 28 (7.8) | 1.57 [0.72–3.53] | 0.25 |
| Age group | |||
| ≥ 5 years | 16 (2.8) | 1 | – |
| < 5 years | 30 (14.6) | 5.74 [2.6–13.1] | 0.0001 |
Notes: Logistic regression stopped with Wald test 31.84 on 4 df (p = 2.066e−06). Only the variables age group (age < 5 years), parasite half-life, and HbCC were significantly linked with the risk of failure.
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