Modeling the population parasite number according to the hemoglobin type. The parasite half-life time is plotted for those with (A) or without (B) abnormal hemoglobin according to the White et al. [27], distribution model. For aHb, the model describes only one phenotype (half-life time = 2.15 ± 1.37 h), whereas for nHb, three phenotypes were found: i) phenotype 1 (blue line, half-life time = 1.83 ± 1.28 h) accounting for 25.4% of the patients, ii) phenotype 2 (red line, half-life time = 3.23 ± 1.17 h) accounting for 66.88% of the patients, and iii) phenotype 3 (pink line, half-life time = 7.78 ± 1.32 h) accounting for 7.73%. The red line highlights the threshold of potential resistance (half-life more than > 5 h). aHb (Abnormal hemoglobin), nHb (Normal hemoglobin).