Open Access
Review Article

Table 2

Sensitivity, Specificity, PPV and NPV of anti-Toxoplasma IgG commercial assays included in the study.

Assay Sensitivity mean % (range) Specificity mean % (range) PPV mean % (range) NPV mean % (range) Comments
Access Toxo IgG II® 89.7 100 100 92.8
Low IgG: 13.4 Low IgG: 99.6
Advia Centaur® 100 100 100 100 Single study
Low IgG: 51.1
Architect Toxo IgG® 90.7 (80.8–99.6) 99.8 (99.5–100) 99.7 (99.1–100) 97.3 (94.6–99.5) For low IgG, one study did not provide crude results [13]
Low IgG: 30.5 (12–43.9) Low IgG: 100
Axsym Toxo IgG® 96.1 (90.2–99.6) 99.7 (99.5–100) 99.7 (99.4–100) 97.2 (93.1–99.5)
BioPlex 2200 ToRCH IgG/IgM® 97.8 91.3 98.5 87.5 Single study
Elecsys Toxo IgG® 98.6 (97.5–100) 99.6 (98.7–100) 99.2 (98.3–100) 99.4 (98.7–100) 100% concordance with DT for sera with interfering diseases
Low IgG: 88.6 (73.2–95.6) Low IgG: 99.6 (99.3–100)
Immulite 2000 anti-Toxoplasma IgG® 93.5 (87.9–99) 99.8 (99.6–100) 99.4 92.7
Liaison Toxo IgG II® 94.8 (93.8–95.8) 99.5 (na) 98.2 (96.8–99.5) 97.4 (95.7–99.1) One study merged results obtained with low and standard IgG titers (58.9% sensitivity)
Low IgG: 25.5 (6.7–58.9) Low IgG: 100
Platelia Toxo IgG® 96.4 (95.6–97.2) 99.4 (98.7–100) 98.4 (96.7–100) 97.7 (97.1–98.3) In one study, only 29/56 discrepant EIA were confirmed by DT
Low IgG: 47.6 (32.9–62.2) Low IgG: 100
TGS TA Toxo IgG/IDS-iSYS® 97 97 nd nd
Low IgG: 46.3 Low IgG: 96.7 Low IgG: 86.4 Low IgG: 79.8
Vidas Toxo IgG® 95.5 (91.4–100) 99.8 (99.5–100) 99.1 (96.8–100) 97.7 (93.9–99.5)
Low IgG: 44.2 (12.2–63.3) Low IgG: 99.7 (99–100)
Vitros ECiQ Toxoplasma IgG® 93.4 100 nd nd Single study, no separate analysis of IgG et IgM results
Pastorex Toxo® 98.8 98.8 98.8 98.8 Single study, 6.5% false-positive with interfering diseases, sensitivity 97.3% and 100% in acute and chronic toxoplasmosis, respectively
Low IgG: 51.5
Toxocell® 96.8 97.6 97.6 96.8 Single study, 11% false-positive results with interfering diseases, Sensitivity 97.3% and 100% in acute and chronic toxoplasmosis, respectively
Low IgG: 66.7
Toxo HAI® 100 99.2 99.2 100 Single study, 4.3% false-positive results with interfering diseases, Sensitivity 97.3% and 100% in acute and chronic toxoplasmosis, respectively
Low IgG: 97
Toxolatex® 93.7 97.1 97.1 93.7 Single study, 11% false-positive results with interfering diseases, Sensitivity 94.6% and 100% in acute and chronic toxoplasmosis, respectively
Low IgG: 51.5
OnSite Toxo IgG/IgM Combo Rapid Test® 100 98 98.8 100 Single study
Detects both specific IgG and IgM
Toxo IgG/IgM Rapid Test ® Biopanda 100 96 98.3 100 Single study
Detects both specific IgG and IgM
Toxoplasma ICT IgG/IgM® LDBio 100 99.1 (98.6–100) 97.6 (95.8–99.4) 100 Detects both specific IgG and IgM, 100% sensitivity in acute infections, 100% concordance with WB Toxo IgGII
WB Toxo IgGII® Low IgG: 99.2 100 100 99.2 Single study, 99.4% NPV, 100% concordance with DT for equivocal sera and interfering diseases

PPV: positive predictive value; NPV: negative positive value; DT: dye-test; na: not applicable; nd: not determined.

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