Table 1
Study designs.
| Field trial | Objective(s) | Location | Date | Positive control | Ratio IVP/PCP | Primary variables of efficacy |
|---|---|---|---|---|---|---|
| USA | Flea efficacy & safety for 3 months, reduction of flea infestation-related cutaneous signs | Southeast, Midwest, Western USA | Apr 2017 – Nov 2018 | Selamectin | 2/1 | Flea reduction at 1 month for sentinel cats |
| EU | Flea efficacy & safety for 1 month, reduction of flea infestation-related cutaneous signs | Western, Central, Eastern Europe | Apr 2017 – Oct 2017 | Fipronil, (S)-methoprene | 2/1 | Weekly flea reduction for sentinel cats for 1 month, non-inferiority versus positive control |
| Japan | Flea efficacy & safety for 1 month | 6 prefectures in Kanto, Chubu and Kyushu | Jul 2017 – Jan 2018 | Selamectin | 1/1 | Flea reduction at 2 days and 1 month (all cats), non-inferiority versus positive control |
| Australia | Flea efficacy & safety for 1 month | NSW, QLD | Jan 2019 – Mar 2019 | NA | NA | Flea reduction at 1 month for sentinel cats |
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