Table 1
Mean pharmacokinetic (PK) parameters in the two groups of animals treated with IVM.
| PK parameters | Value | Treatment group |
|
|---|---|---|---|
| 500 mg (1.5–2 mg/kg) | 1000 mg (3–4 mg/kg) | ||
| Cmax (ng/mL) | Mean | 16.3 | 36.2 |
| SD | 5.4 | 6.9 | |
| CV (%) | 33.2 | 19.1 | |
| Tmax (days) | Median | 2.00 | 0.25 |
| Clast (ng/mL) | Mean | 3.10 | 6.02 |
| SD | 1.23 | 1.55 | |
| AUC0–tlast (ng day/mL) | Mean | 1239 | 3116 |
| SD | 636 | 581 | |
Cmax = maximum observed plasma concentration; Tmax = time of maximum observed plasma concentration; Clast = last measurable concentration (above the quantification limit); AUC0–tlast = area under the concentration-time curve to the last measurable concentration; SD = standard deviation; CV = coefficient of variation.
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