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Table 1

Characterization of the metacaspase protein in different Leishmania species. ND: not determined.

Species Gene ID Wild-type expression Processing Localization Enzymatic activity Apoptotic stimuli inducing MCA activity Role other than in apoptosis References
L. major LmjF.35.1580 In promastigotes and amastigotes Auto-processing Depends on the cell cycle phase; cytoplasm and mitochondrion; associated with the kinetoplast and the mitotic spindle Trypsine-like activity (no caspase-like activity), catalytic dyad (H147/C202) H2O2, heat shock, miltefosine, curcumin Autophagy González et al. (2007) [35]; Ambit et al. (2008) [2]; Zalila et al. (2011) [73]; Basmaciyan et al. (2018) [7]
L. donovani LdBPK_35180.1 In promastigotes and axenic amastigotes No processing Acidocalcisomes (inhibited?) Trypsine-like activity (no caspase-like activity), catalytic dyad (H147/C202) H2O2 ND Lee et al. (2007) [44]
L. mexicana LmxM.34.1580 ND ND Mainly cytoplasmic Catalytic dyad (H147/C202) Miltefosine (not H2O2 and not camptothecin) Negative regulator of intracellular amastigote proliferation Castanys-Muñoz et al. (2012) [17]

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