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Proposed model of the different L. major cell death pathways. It is currently clear that different pro-apoptotic stimuli can induce different cell death pathways in L. major. While miltefosine induces LmjMCA and then LmjHYD36 and LmjF.22.0600 activation before activating EndoG, the amphotericin B and H2O2-induced cell death pathways involve unknown proteins. Curcumin and pentamidine, on the contrary, only activate LmjHYD36. The relationships between curcumin and LmjMCA and between LmjHYD36 and LmjMCA, on the one hand, and EndoG on the other, remain to be elucidated.
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