Open Access
Review Article

Figure 4


Download original image

Proposed model of the different L. major cell death pathways. It is currently clear that different pro-apoptotic stimuli can induce different cell death pathways in L. major. While miltefosine induces LmjMCA and then LmjHYD36 and LmjF.22.0600 activation before activating EndoG, the amphotericin B and H2O2-induced cell death pathways involve unknown proteins. Curcumin and pentamidine, on the contrary, only activate LmjHYD36. The relationships between curcumin and LmjMCA and between LmjHYD36 and LmjMCA, on the one hand, and EndoG on the other, remain to be elucidated.

Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.

Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.

Initial download of the metrics may take a while.