Treatment of canine sarcoptic mange with afoxolaner (NexGard®) and afoxolaner plus milbemycin oxime (NexGard Spectra®) chewable tablets: efficacy under field conditions in Portugal and Germany

Verena Hampel; Martin Knaus; Jürgen Schäfer; Frederic Beugnet; Steffen Rehbein

doi:10.1051/parasite/2018064

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Volume 25 (2018)

Parasite, 25 (2018) 63

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Research Article

Table 2.

Summary and analysis of clinical signs of Sarcoptes scabiei var. canis naturally infested dogs administered either NexGard^® or NexGard Spectra^® per label instructions twice, one month apart (Visit 1 and Visit 2).

Clinical sign and score	Number of dogs per score/Number of dogs examined
Clinical sign and score	Visit 1, baseline (pre-treatment)	Visit 2, one month after Visit 1	Visit 3, one month after Visit 2
Pruritus
NexGard ^®
No scratching	0/38	34/38	37/38
Occasional scratching	10/38	4/38	1/38
Constant scratching	28/38	0/38	0/38
p-value (Generalized McNemar test)		0.0001	0.0001
NexGard Spectra ^®
No scratching	0/27	24/27	26/27
Occasional scratching	8/27	3/27	1/27
Constant scratching	19/27	0/27	0/27
p-value (Generalized McNemar test)		0.0001	0.0001
Papules and crusts
NexGard ^®
No papules or crusts	0/38	31/38	36/38
Occasional papules or crusts	8/38	6/38	2/38
Numerous papules or crusts	30/38	1/38	0/38
p-value (Generalized McNemar test)		0.0001	0.0001
NexGard Spectra ^®
No papules or crusts	0/27	18/27	25/27
Occasional papules or crusts	7/27	9/27	2/27
Numerous papules or crusts	20/27	0/27	0/27
p-value (Generalized McNemar test)		0.0001	0.0001
Alopecia
NexGard ^®
No alopecia (hair re-growth)	0/38	21/38	30/38
Areas with alopecia with partial hair (re-)growth	6/38	17/38	8/38
Areas with alopecia with no hair re-growth	32/38	0/38	0/38
p-value (Generalized McNemar test)		0.0001	0.0001
NexGard Spectra ^®
No alopecia (hair re-growth)	0/27	9/27	20/27
Areas with alopecia with partial hair (re-)growth	3/27	17/27	7/27
Areas with alopecia with no hair re-growth	24/27	1/27	0/27
p-value (Generalized McNemar test)		0.0001	0.0001

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