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Table 2.
Summary and analysis of clinical signs of Sarcoptes scabiei var. canis naturally infested dogs administered either NexGard® or NexGard Spectra® per label instructions twice, one month apart (Visit 1 and Visit 2).
| Clinical sign and score | Number of dogs per score/Number of dogs examined |
||
|---|---|---|---|
| Visit 1, baseline (pre-treatment) | Visit 2, one month after Visit 1 | Visit 3, one month after Visit 2 | |
| Pruritus | |||
| NexGard ® | |||
| No scratching | 0/38 | 34/38 | 37/38 |
| Occasional scratching | 10/38 | 4/38 | 1/38 |
| Constant scratching | 28/38 | 0/38 | 0/38 |
| p-value (Generalized McNemar test) | 0.0001 | 0.0001 | |
| NexGard Spectra ® | |||
| No scratching | 0/27 | 24/27 | 26/27 |
| Occasional scratching | 8/27 | 3/27 | 1/27 |
| Constant scratching | 19/27 | 0/27 | 0/27 |
| p-value (Generalized McNemar test) | 0.0001 | 0.0001 | |
| Papules and crusts | |||
| NexGard ® | |||
| No papules or crusts | 0/38 | 31/38 | 36/38 |
| Occasional papules or crusts | 8/38 | 6/38 | 2/38 |
| Numerous papules or crusts | 30/38 | 1/38 | 0/38 |
| p-value (Generalized McNemar test) | 0.0001 | 0.0001 | |
| NexGard Spectra ® | |||
| No papules or crusts | 0/27 | 18/27 | 25/27 |
| Occasional papules or crusts | 7/27 | 9/27 | 2/27 |
| Numerous papules or crusts | 20/27 | 0/27 | 0/27 |
| p-value (Generalized McNemar test) | 0.0001 | 0.0001 | |
| Alopecia | |||
| NexGard ® | |||
| No alopecia (hair re-growth) | 0/38 | 21/38 | 30/38 |
| Areas with alopecia with partial hair (re-)growth | 6/38 | 17/38 | 8/38 |
| Areas with alopecia with no hair re-growth | 32/38 | 0/38 | 0/38 |
| p-value (Generalized McNemar test) | 0.0001 | 0.0001 | |
| NexGard Spectra ® | |||
| No alopecia (hair re-growth) | 0/27 | 9/27 | 20/27 |
| Areas with alopecia with partial hair (re-)growth | 3/27 | 17/27 | 7/27 |
| Areas with alopecia with no hair re-growth | 24/27 | 1/27 | 0/27 |
| p-value (Generalized McNemar test) | 0.0001 | 0.0001 | |
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