Table 1
Performance comparison between LAMP and microscopy or real-time PCR. Sensitivity, specificity, positive predictive value and negative predictive value were calculated based on 299 samples, excluding the 11 invalid results from LAMP. The number of samples used for microscopy are 79 positive (83–4 invalid excluded) and 220 negative (227–7 invalid excluded). The number of samples used for PCR are 85 positive (89–4 invalid excluded) and 214 negative (221–7 invalid excluded).
| Microscopy | Real-time PCR | ||||||
|---|---|---|---|---|---|---|---|
| + | − | total | + | − | total | ||
| LAMP | + | 79 | 14 | 93 | 85 | 4 | 89 |
| − | 0 | 206 | 206 | 0 | 210 | 210 | |
| 79 | 220 | 299 | 85 | 214 | 299 | ||
| Versus microscopy | Versus real-time PCR | |||
|---|---|---|---|---|
| LAMP performance | % | 95% confidence interval (%) | % | 95% confidence interval (%) |
| Sensitivity | 100 | 95.55 to 100 | 100 | 95.75 to 100 |
| Specificity | 93.64 | 89.55 to 96.48 | 98.13 | 95.28 to 99.49 |
| Positive predictive value | 84.95 | 77.27 to 90.35 | 95.51 | 88.95 to 98.25 |
| Negative predictive value | 100 | n.a. | 100 | n.a. |
| Positive likelihood ratio | 15.7 | n.a. | 53.5 | n.a. |
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