Summary of published work on the efficacy of experimental HIFU against E. granulosus.
|Target||Summary of the procedure||Results||References|
|Cysts ex vivo||Cysts treated with 150 W or 250 W sound power respectively.||Detachment and disruption of the germinal layer.|| Chinese|
|PSC in vitro||PSC suspension treated with different combinations of sound power (0–250 W) and time (5–60 s).||Dose-dependent damage and death of PSC; growth inhibition and mortality of survived PSC cultured in vitro; inhibition of infectivity of survived PSC in secondary infection mouse model.|||
|Cysts from mouse secondary infection ex vivo||Three groups, treated with 4 W, 9 W or 13 W sound power for 1 min.||Damage of the laminated and germinal layers.|| Chinese|
|PSC in vitro||PSC suspension treated with 100 W acoustic power for 5–60 s with or without SAP.||Dose-dependent damage and death of treated PSC, enhanced in the presence of SAP.|||
|Cysts ex vivo||Cysts treated with 100 W sound power for 3 s each area for three times at a scanning speed of 3 mm/s with or without injection of SAP or UCA alone or in combination.||Change in ultrasound echo pattern after treatment; increased mortality rate of PSC after treatment HIFU alone < SAP or UCA-aided HIFU < SAP + UCA-aided HIFU; damage of the laminated and germinal layers.|||
|Cysts transplanted IP in rabbit in vivo model||Cysts transplanted IP in rabbits after ± injection of SAP or UCA or both; HIFU applied as in .||Change in ultrasound echo pattern after treatment; increased mortality rate of PSC after treatment HIFU alone < SAP or UCA-aided HIFU < SAP + UCA-aided HIFU; damage of the laminated and germinal layers; no pathologic effects on rabbit skin.|||
PSC, protoscolices; SAP, superabsorbent polymer; UCA, ultrasound contrast agent.
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