The lung injuries are progressive during the course of infection. Uninfected mice (uninf.), mice infected by L. sigmodontis (L. s), mice infected by P. yoelii (P. y) and mice co-infected by P. y + L. s were analysed throughout the infection from day 4 (D4) to day 30 (D30) post-infection; mice infected by P. chabaudi (P. c) and mice co-infected by P. c + L. s were analysed at the later time points, e.g., D13 and D30. (A) Normal lung at day 4 in all groups. (B) Lung with an increased cellular density at day 7 (D7) in P. y-infected mice, with or without L. s. (C) Lung with congestion and high number of cells at day 13 (D13) in all plasmodial infected groups. (D) Lung with higher congestion and high number of cells (D30) in all plasmodial infected groups. E. Lung with heavy congestion and haemorrhagic alveolitis at day 30 (D30) in P. c-infected mice, with or without L. s. Scale bars represent 50 μm.